@article {Jayasuriya516, author = {A N Jayasuriya and R F Itzhaki and M A Wozniak and R Patel and E J Smit and R Noone and G Gilleran and S Taylor and D J White}, title = {Apolipoprotein E-ϵ4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV}, volume = {84}, number = {7}, pages = {516--517}, year = {2008}, doi = {10.1136/sti.2008.032367}, publisher = {The Medical Society for the Study of Venereal Disease}, abstract = {Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-ϵ4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-ϵ4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95\% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-ϵ4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.}, issn = {1368-4973}, URL = {https://sti.bmj.com/content/84/7/516}, eprint = {https://sti.bmj.com/content/84/7/516.full.pdf}, journal = {Sexually Transmitted Infections} }