TY - JOUR T1 - Apolipoprotein E-ϵ4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 516 LP - 517 DO - 10.1136/sti.2008.032367 VL - 84 IS - 7 AU - A N Jayasuriya AU - R F Itzhaki AU - M A Wozniak AU - R Patel AU - E J Smit AU - R Noone AU - G Gilleran AU - S Taylor AU - D J White Y1 - 2008/12/01 UR - http://sti.bmj.com/content/84/7/516.abstract N2 - Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-ϵ4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-ϵ4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-ϵ4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV. ER -