%0 Journal Article %A Audrey E Pettifor %A Catherine MacPhail %A Stefano Bertozzi %A Helen V Rees %T Challenge of evaluating a national HIV prevention programme: the case of loveLife, South Africa %D 2007 %R 10.1136/sti.2006.023689 %J Sexually Transmitted Infections %P i70-i74 %V 83 %N suppl 1 %X Although 50% of all new global HIV infections occur among young people, our knowledge to date of the impact of adolescent HIV prevention interventions in developing country settings is limited. During 1999, a national HIV prevention programme for youth, called loveLife, was launched in South Africa. This paper describes the challenges faced in trying to evaluate such a national programme and the types of evidence that could be used to better understand the effect of programmes of national scale. A range of methods were planned to evaluate the programme, including national household surveys and programme monitoring data. Given the urgent need to scale-up programmes in an effort to reduce new HIV infections, a range of evidence should be assessed to measure the effect of large-scale, complex behavioural interventions as an alternative to randomised controlled trials. %U https://sti.bmj.com/content/sextrans/83/suppl_1/i70.full.pdf