PT - JOURNAL ARTICLE AU - H Moi AU - N Reinton AU - A Moghaddam TI - <em>Mycoplasma genitalium</em> is associated with symptomatic and asymptomatic non-gonococcal urethritis in men AID - 10.1136/sti.2008.032730 DP - 2009 Feb 01 TA - Sexually Transmitted Infections PG - 15--18 VI - 85 IP - 1 4099 - http://sti.bmj.com/content/85/1/15.short 4100 - http://sti.bmj.com/content/85/1/15.full SO - Sex Transm Infect2009 Feb 01; 85 AB - Objectives: To examine the prevalence of Mycoplasma genitalium in a large number of male patients attending a sexually transmitted infections (STI) clinic and to determine if there is an association with objective non-gonococcal urethritis (NGU) in patients with and without clinical symptoms.Methods: Patients were tested for both M genitalium and Chlamydia trachomatis if they had symptoms or microscopic signs of NGU or if they were perceived to be at high-risk of exposure to a STI (nā€Š=ā€Š8468). Urethral smears were examined for polymorphic mononuclear leucocytes.Results: We found that M genitalium infection was associated with symptoms of non-chlamydial NGU (discharge and dysuria; OR 4.3; 95% CI 3.4 to 5.5). We also found that M genitalium infection was associated with signs of non-chlamydial NGU independently with or without symptoms of NGU (with symptoms: OR 4.7; 95% CI 3.2 to 6.7; without symptoms: OR 3.1; 95% CI 2.0 to 4.6). Prevalence of M genitalium was also associated with severity of urethritis as quantified by microscopic examination of urethral smears.Conclusions: These data add further evidence to the association of M genitalium infection with NGU and should allow better risk analysis of recent recommendations of not performing urethral smears in asymptomatic men attending STI clinics.