PT  - JOURNAL ARTICLE
AU  - Eduard J Sanders
AU  - Alexander N Thiong'o
AU  - Haile Selassie Okuku
AU  - John Mwambi
AU  - Frances Priddy
AU  - Juma Shafi
AU  - Henry de Vries
AU  - R Scott McClelland
AU  - Susan M Graham
TI  - High prevalence of <em>Chlamydia trachomatis</em> and <em>Neisseria gonorrhoeae</em> infections among HIV-1 negative men who have sex with men in coastal Kenya
AID  - 10.1136/sti.2010.043224
DP  - 2010 Nov 01
TA  - Sexually Transmitted Infections
PG  - 440--441
VI  - 86
IP  - 6
4099  - http://sti.bmj.com/content/86/6/440.short
4100  - http://sti.bmj.com/content/86/6/440.full
SO  - Sex Transm Infect2010 Nov 01; 86
AB  - Objectives To assess the burden of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in high-risk HIV-1 negative men who have sex with men (MSM) in Africa.Methods Before the start of a pre-exposure prophylaxis trial, HIV-1 negative volunteers were screened for sexually transmitted infection (STI) including CT and NG, using a highly sensitive and specific nucleic acid amplification test. Samples positive for CT by Aptima testing, were evaluated for the presence of lymphogranuloma venereum (LGV) serovars using an in-house PCR assay. All men were asked to submit a urine specimen, and all had a rectal swab collected by a clinician. Men were asked if they had dysuria, urethral or rectal discharge, or rectal pain.Results 43 HIV-1 negative MSM were screened, of whom 13 reported sex with men only; the majority (27/43) reported sex work. One volunteer had dysuria and another, rectal pain. Eleven MSM (26%, 95% CI 14% to 41%) had infections with either or both pathogens. Homosexual men had a higher prevalence of any infection than bisexual men (46% vs 17%, p=0.04), and all cases of rectal infections, including one with CT, two with NG and two with CT/NG co-infection. All patients with CT were negative for LGV. One patient with a rectal NG infection reported rectal pain.Conclusions A remarkably high burden of STI infection was found among HIV-1 negative MSM. Most (12/13) infections, including three of four rectal NG infections, were subclinical. These findings suggest that high-risk MSM will benefit from effective STI screening in Kenya.