PT  - JOURNAL ARTICLE
AU  - N T Annan
AU  - A K Sullivan
AU  - A Nori
AU  - P Naydenova
AU  - S Alexander
AU  - A McKenna
AU  - B Azadian
AU  - S Mandalia
AU  - M Rossi
AU  - H Ward
AU  - N Nwokolo
TI  - Rectal chlamydia—a reservoir of undiagnosed infection in men who have sex with men
AID  - 10.1136/sti.2008.031773
DP  - 2009 Jun 01
TA  - Sexually Transmitted Infections
PG  - 176--179
VI  - 85
IP  - 3
4099  - http://sti.bmj.com/content/85/3/176.short
4100  - http://sti.bmj.com/content/85/3/176.full
SO  - Sex Transm Infect2009 Jun 01; 85
AB  - Objective: To determine the prevalence of rectal chlamydia infection in a cohort of men who have sex with men (MSM) and the proportion of infection that would be missed without routine screening. Methods: MSM presenting to four HIV/GUM outpatient clinics at the Chelsea & Westminster Hospital NHS Foundation Trust between 1 November 2005 and 29 September 2006 were offered testing for rectal chlamydia infection in addition to their routine screen for sexually transmitted infections (STIs). Chlamydia trachomatis (CT) tests were performed using the Beckton-Dickinson Probe-Tec Strand Displacement Assay. Positive samples were re-tested at the Sexually Transmitted Bacteria Reference Laboratory, to confirm the result and identify lymphogranuloma venereum (LGV)-associated serovars. Results: A total of 3076 men were screened. We found an 8.2% prevalence of infection with CT (LGV and non-LGV serovars) in the rectum and 5.4% in the urethra. The HIV and rectal chlamydia co-infection rate was 38.1%. The majority of rectal infections (69.2%, (171/247)) were asymptomatic and would have been missed if routine screening had not been undertaken. Of the samples re-tested, 94.2% (227/242) rectal and 91.8% (79/86) urethral specimens were confirmed CT positive and 36 cases of LGV were identified. Conclusion: Our data show a high rate of rectal chlamydia infection, in the majority of cases it was asymptomatic. We recommend routine screening for rectal chlamydia in men at risk, as this may represent an important reservoir for the onward transmission of infection.