@article {Bax503, author = {C J Bax and K D Quint and R P H Peters and S Ouburg and P M Oostvogel and J A E M Mutsaers and P J D{\"o}rr and S Schmidt and C Jansen and A P van Leeuwen and W G V Quint and J B Trimbos and C J L M Meijer and S A Morr{\'e}}, title = {Analyses of multiple-site and concurrent Chlamydia trachomatis serovar infections, and serovar tissue tropism for urogenital versus rectal specimens in male and female patients}, volume = {87}, number = {6}, pages = {503--507}, year = {2011}, doi = {10.1136/sti.2010.048173}, publisher = {The Medical Society for the Study of Venereal Disease}, abstract = {Objectives The aims of this study were: to determine the incidence of concurrent infections on a serovar level; to determine the incidence of multiple anatomical infected sites on a detection and genotyping level and analyse site-specific serovar distribution; to identify tissue tropism in urogenital versus rectal specimens.Methods Chlamydia trachomatis-infected patients in two populations were analysed: 75 visiting the outpatient department of obstetrics and gynaecology of the MC Haaglanden, and 358 visiting the outpatient sexually transmitted disease clinic, The Hague, The Netherlands. The PACE 2 assay (Gen-Probe) was used to detect C trachomatis from urethral, cervical, vaginal, oropharyngeal and anorectal swabs. C trachomatis genotyping was performed on all C trachomatis positive samples, using the CT-DT genotyping assay.Results Samples from 433 patients (256 female and 177 male) with confirmed C trachomatis infection were analysed. In 11 patients (2.6\%), concurrent serovars in one anatomical sample site were present. In 62 (34.1\%) female and four (9.3\%) male patients, multiple sample site infections were found. A substantial percentage of women tested at the cervical/vaginal and rectal site were found to be positive at both sites (36.1\%, 22/61). In men, D/Da and G/Ga serovars were more prevalent in rectal than urogenital specimens (p=0.0081 and p=0.0033, respectively), while serovar E was more prevalent in urogenital specimens (p=0.0012).Conclusions The prevalence of multiple serovar infections is relatively low. Significant differences in serovar distribution are found in rectal specimens from men, with serovar G/Ga being the most prominent, suggesting tissue tropism.}, issn = {1368-4973}, URL = {https://sti.bmj.com/content/87/6/503}, eprint = {https://sti.bmj.com/content/87/6/503.full.pdf}, journal = {Sexually Transmitted Infections} }