RT Journal Article
SR Electronic
T1 Analyses of multiple-site and concurrent <em>Chlamydia trachomatis</em> serovar infections, and serovar tissue tropism for urogenital versus rectal specimens in male and female patients
JF Sexually Transmitted Infections
JO Sex Transm Infect
FD BMJ Publishing Group Ltd
SP 503
OP 507
DO 10.1136/sti.2010.048173
VO 87
IS 6
A1 C J Bax
A1 K D Quint
A1 R P H Peters
A1 S Ouburg
A1 P M Oostvogel
A1 J A E M Mutsaers
A1 P J Dörr
A1 S Schmidt
A1 C Jansen
A1 A P van Leeuwen
A1 W G V Quint
A1 J B Trimbos
A1 C J L M Meijer
A1 S A Morré
YR 2011
UL http://sti.bmj.com/content/87/6/503.abstract
AB Objectives The aims of this study were: to determine the incidence of concurrent infections on a serovar level; to determine the incidence of multiple anatomical infected sites on a detection and genotyping level and analyse site-specific serovar distribution; to identify tissue tropism in urogenital versus rectal specimens.Methods Chlamydia trachomatis-infected patients in two populations were analysed: 75 visiting the outpatient department of obstetrics and gynaecology of the MC Haaglanden, and 358 visiting the outpatient sexually transmitted disease clinic, The Hague, The Netherlands. The PACE 2 assay (Gen-Probe) was used to detect C trachomatis from urethral, cervical, vaginal, oropharyngeal and anorectal swabs. C trachomatis genotyping was performed on all C trachomatis positive samples, using the CT-DT genotyping assay.Results Samples from 433 patients (256 female and 177 male) with confirmed C trachomatis infection were analysed. In 11 patients (2.6%), concurrent serovars in one anatomical sample site were present. In 62 (34.1%) female and four (9.3%) male patients, multiple sample site infections were found. A substantial percentage of women tested at the cervical/vaginal and rectal site were found to be positive at both sites (36.1%, 22/61). In men, D/Da and G/Ga serovars were more prevalent in rectal than urogenital specimens (p=0.0081 and p=0.0033, respectively), while serovar E was more prevalent in urogenital specimens (p=0.0012).Conclusions The prevalence of multiple serovar infections is relatively low. Significant differences in serovar distribution are found in rectal specimens from men, with serovar G/Ga being the most prominent, suggesting tissue tropism.