PT  - JOURNAL ARTICLE
AU  - Chotmongkol, Verajit
AU  - Sawanyawisuth, Kittisak
AU  - Yimtae, Kwanchanok
AU  - Chantarojanasiri, Thanyaporn
AU  - Chotmongkol, Ratchanee
TI  - Doxycycline treatment of otosyphilis with hearing loss
AID  - 10.1136/sextrans-2011-050201
DP  - 2012 Apr 01
TA  - Sexually Transmitted Infections
PG  - 177--178
VI  - 88
IP  - 3
4099  - http://sti.bmj.com/content/88/3/177.short
4100  - http://sti.bmj.com/content/88/3/177.full
SO  - Sex Transm Infect2012 Apr 01; 88
AB  - Objectives The recommended treatment of otosyphilis is intravenous penicillin therapy. The response rate varied between 23% and 31%. This treatment needs hospitalisation and is costly, inconvenient and time consuming. Oral doxycycline was tested for its efficacy in otosyphilis.Method The authors reviewed 19 patients diagnosed as having otosyphilis with hearing loss at the outpatient unit between 2004 and 2008 by oral doxycycline 400 mg/day for 21 days.Results Of those enrolled patients, 12 patients were male and the mean age is 69.4 years. The hearing was improved in nine patients (47.3%) and the audiogram of seven patients (36.8%) showed improvement. There was no serious side effect of doxycycline.Conclusion The data suggest that doxycycline may be an effective alternate regimen for otosyphilis.