PT  - JOURNAL ARTICLE
AU  - Ryoichi Hamasuna
AU  - Satoshi Takahashi
AU  - Hiroshi Kiyota
AU  - Mitsuru Yasuda
AU  - Hiroshi Hayami
AU  - Soichi Arakawa
AU  - Kazunori Tomono
AU  - Tetsuro Matsumoto
TI  - Effect of gatifloxacin against <em>Mycoplasma genitalium</em>-related urethritis: an open clinical trial
AID  - 10.1136/sti.2010.048553
DP  - 2011 Aug 01
TA  - Sexually Transmitted Infections
PG  - 389--390
VI  - 87
IP  - 5
4099  - http://sti.bmj.com/content/87/5/389.short
4100  - http://sti.bmj.com/content/87/5/389.full
SO  - Sex Transm Infect2011 Aug 01; 87
AB  - Objectives Mycoplasma genitalium and Chlamydia trachomatis are the primary pathogens detected from non-gonococcal urethritis (NGU). In this study, the efficacy of gatifloxacin was examined against M genitalium-related urethritis.Methods The study was an open clinical trial evaluating the effectiveness of gatifloxacin with 200 mg doses twice a day for 7 days against male NGU.Results Between March and September 2008, 169 male patients were enrolled, and microbiological and clinical cure rates could be evaluated in 86 patients detected with C trachomatis or M genitalium and in 135 with NGU, respectively. Microbiological cure rates of gatifloxacin against C trachomatis and M genitalium were 100% and 83%, respectively, and the total clinical cure rate was 99%.Conclusion Analysis of in-vivo and in-vitro data from the literature of fluoroquinolone efficacies against M genitalium suggests that a MIC90 of 0.125 μg/ml or less may be useful for optimal activity against M genitalium infection.