PT  - JOURNAL ARTICLE
AU  - Aaron A R Tobian
AU  - Charlotte Gaydos
AU  - Ronald H Gray
AU  - Godfrey Kigozi
AU  - David Serwadda
AU  - Nicole Quinn
AU  - Mary K Grabowski
AU  - Richard Musoke
AU  - Anthony Ndyanabo
AU  - Fred Nalugoda
AU  - Maria J Wawer
AU  - Thomas C Quinn
TI  - Male circumcision and <em>Mycoplasma genitalium</em> infection in female partners: a randomised trial in Rakai, Uganda
AID  - 10.1136/sextrans-2013-051293
DP  - 2014 Mar 01
TA  - Sexually Transmitted Infections
PG  - 150--154
VI  - 90
IP  - 2
4099  - http://sti.bmj.com/content/90/2/150.short
4100  - http://sti.bmj.com/content/90/2/150.full
SO  - Sex Transm Infect2014 Mar 01; 90
AB  - Objective Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men. Methods HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers. Results Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97). Conclusions Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.