RT Journal Article
SR Electronic
T1 S09.3 Herpes Simplex Virus
JF Sexually Transmitted Infections
JO Sex Transm Infect
FD BMJ Publishing Group Ltd
SP A16
OP A16
DO 10.1136/sextrans-2013-051184.0049
VO 89
IS Suppl 1
A1 E Frobert
A1 S Ducastelle-Lepretre
A1 J Casalegno
A1 V Nave
A1 D Eibach
A1 B Lina
A1 F Morfin
YR 2013
UL http://sti.bmj.com/content/89/Suppl_1/A16.2.abstract
AB The more and more frequent and widespread use of acyclovir (ACV), but also the increasing number of immunocompromised patients might induce an increase in HSV (Herpes Simplex Virus) resistance. HSV resistance to ACV is mainly associated with mutations in the thymidine kinase (TK) gene although mutations in the DNA polymerase can be observed. Up to now, resistance of HSV to ACV was a major concern for immunocompromised patients with a frequency between 2.5 and 10%. This study aimed to reassess HSV resistance to ACV, during a ten year period, in immunocompetent and in immunocompromised patients (bone marrow transplant patients, solid organ transplant, HIV positive patients, cancer patients). From 2002 to 2011, 1538 patients positive for HSV were tested for the susceptibility of their virus to ACV (1044 immunocompetent and 494 immunocompromised). In immunocompetent patients, prevalence of resistance remains under 0.5%, whatever the period studies. In immunocompromised patients, a significant increase can be observed, from 4.3% during 2002–2006 (11/255 patients) to 13.4% during 2007–2011 (32/239) (p = 0.0002). This significant increase is mainly observed among bone marrow transplant patients in which the prevalence is 10% (5/52) during 2002–2006 and 38% (30/79) during 2007–2011 (p = 0.0002), whereas other types of immune deficiencies do not show an increase (1.3% versus 2.9%, p = 0.2). New chemotherapy protocols (FLAMSA) and type of transplantation as blood cord transplant are part of the explanation. Genotyping of the resistant viruses (35 viruses) reveal mutations in the TK gene for 80% of them. Double population including resistant and susceptible viruses were recovered in 5 isolates (5/34 = 14%). Rapid diagnosis of HSV resistance, but also research on alternative treatment are more than ever of interest.