TY - JOUR T1 - Response to: A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to <em>Treponema pallidum</em>? JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 313 LP - 313 DO - 10.1136/sextrans-2017-053212 VL - 93 IS - 5 AU - David V Glidden AU - Kenneth Mayer AU - Robert M Grant Y1 - 2017/08/01 UR - http://sti.bmj.com/content/93/5/313.abstract N2 - The authors impute a biological mechanism to the high incidence of syphilis in men who have sex with men using antiretroviral pre-exposure prophylaxis (PrEP), when empiric data do not support the biological hypothesis, and behavioural explanations (ie, increased condomless sex and selection of higher risk partners) are supported by stronger evidence. Randomised double-blind trials of PrEP for HIV prevention1 provide a rigorous test of the author's hypothesis. The … ER -