TY - JOUR T1 - Cross-sectional study to evaluate <em>Trichomonas vaginalis</em> positivity in women tested for <em>Neisseria gonorrhoeae</em> and <em>Chlamydia trachomatis</em>, attending genitourinary medicine and primary care clinics in Bristol, South West England JF - Sexually Transmitted Infections JO - Sex Transm Infect DO - 10.1136/sextrans-2016-052942 SP - sextrans-2016-052942 AU - Jane E Nicholls AU - Katy M E Turner AU - Paul North AU - Ralph Ferguson AU - Margaret T May AU - Karen Gough AU - John Macleod AU - Peter Muir AU - Patrick J Horner Y1 - 2017/05/22 UR - http://sti.bmj.com/content/early/2017/08/09/sextrans-2016-052942.abstract N2 - Background Highly sensitive, commercial nucleic acid amplification tests (NAAT) for Trichomonas vaginalis have only recently been recommended for use in the UK. While testing for T. vaginalis is routine in symptomatic women attending genitourinary medicine (GUM) clinics, it is rare in asymptomatic women or those attending primary care. The aim of this study was to evaluate the positivity of T. vaginalis using a commercial NAAT, in symptomatic and asymptomatic women undergoing testing for chlamydia and gonorrhoea in GUM and primary care settings.Methods Samples from 9186 women undergoing chlamydia and gonorrhoea testing in South West England between May 2013 and Jan 2015 were also tested for T. vaginalis by NAAT alongside existing tests.Results T. vaginalis positivity using NAAT was as follows: in GUM 4.5% (24/530, symptomatic) and 1.7% (27/1584, asymptomatic); in primary care 2.7% (94/3499, symptomatic) and 1.2% (41/3573, asymptomatic). Multivariable regression found that in GUM older age, black ethnicity and deprivation were independent risk factors for T. vaginalis infection. Older age and deprivation were also risk factors in primary care. Testing women presenting with symptoms in GUM and primary care using TV NAATs is estimated to cost £260 per positive case diagnosed compared with £716 using current microbiological tests.Conclusions Aptima TV outperforms existing testing methods used to identify T. vaginalis infection in this population. An NAAT should be used when testing for T. vaginalis in women who present for testing with symptoms in primary care and GUM, based on test performance and cost. ER -