TY - JOUR T1 - Ten years transmission of the new variant of <em>Chlamydia trachomatis</em> in Sweden: prevalence of infections and associated complications JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 100 LP - 104 DO - 10.1136/sextrans-2016-052992 VL - 94 IS - 2 AU - Jenny Dahlberg AU - Ronza Hadad AU - Karin Elfving AU - Inger Larsson AU - Jenny Isaksson AU - Anders Magnuson AU - Hans Fredlund AU - Magnus Unemo AU - Bjőrn Herrmann Y1 - 2018/03/01 UR - http://sti.bmj.com/content/94/2/100.abstract N2 - Objectives In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications.Methods C. trachomatis-positive specimens collected from 2007 to 2015 were analysed by a specific PCR to identify nvCT cases. Genotyping was performed by multilocus sequence typing (MLST) and ompA sequencing. Ectopic pregnancy and pelvic inflammatory disease records were extracted from the national registers.Results In total, 5101 C. trachomatis-positive samples were analysed. The nvCT proportion significantly decreased in the two counties using Roche systems, from 56% in 2007 to 6.5% in 2015 (p&lt;0.001). In the two counties using BD systems, a decrease was also seen, from 19% in 2007 to 5.2% in 2015 (p&lt;0.001). Fifteen nvCT cases from 2015 and 102 cases from 2006 to 2009 had identical MLST profiles. Counties using Roche/Abbott systems showed higher mean rates of ectopic pregnancy and pelvic inflammatory disease compared with counties using BD systems.Conclusions The nvCT proportion has decreased in all counties and converged to a low prevalence irrespective of previous rates. Genotyping showed that nvCT is clonal and genetically stable. Failing detection only marginally affected complication rates. ER -