RT Journal Article SR Electronic T1 100 years of STIs in the UK: a review of national surveillance data JF Sexually Transmitted Infections JO Sex Transm Infect FD BMJ Publishing Group Ltd SP sextrans-2017-053273 DO 10.1136/sextrans-2017-053273 A1 Hamish Mohammed A1 Paula Blomquist A1 Dana Ogaz A1 Stephen Duffell A1 Martina Furegato A1 Marta Checchi A1 Neil Irvine A1 Lesley A Wallace A1 Daniel Rhys Thomas A1 Anthony Nardone A1 J Kevin Dunbar A1 Gwenda Hughes YR 2018 UL http://sti.bmj.com/content/early/2018/04/12/sextrans-2017-053273.abstract AB Objectives The 1916 Royal Commission on Venereal Diseases was established in response to epidemics of syphilis and gonorrhoea in the UK. In the 100 years since the Venereal Diseases Act (1917), the UK has experienced substantial scientific, economic and demographic changes. We describe historical and recent trends in STIs in the UK.Methods We analysed surveillance data derived from STI clinics’ statistical returns from 1917 to 2016.Results Since 1918, gonorrhoea and syphilis diagnoses have fluctuated, reflecting social, economic and technological trends. Following spikes after World Wars I and II, rates declined before re-emerging during the 1960s. At that time, syphilis was more common in men, suggestive of transmission within the men who have sex with men (MSM) population. Behaviour change following the emergence of HIV/AIDS in the 1980s is thought to have facilitated a precipitous decline in diagnoses of both STIs in the mid-1980s. Since the early 2000s, gonorrhoea and syphilis have re-emerged as major public health concerns due to increased transmission among MSM and the spread of antimicrobial-resistant gonorrhoea. Chlamydia and genital warts are now the most commonly diagnosed STIs in the UK and have been the focus of public health interventions, including the national human papillomavirus vaccination programme, which has led to substantial declines in genital warts in young people, and the National Chlamydia Screening Programme in England. Since the 1980s, MSM, black ethnic minorities and young people have experienced the highest STI rates.Conclusion Although diagnoses have fluctuated over the last century, STIs continue to be an important public health concern, often affecting more marginalised groups in society. Prevention must remain a public health priority and, as we enter a new era of sexual healthcare provision including online services, priority must be placed on maintaining prompt access for those at greatest risk of STIs.