TY - JOUR T1 - P386 Cancer risk among people with HIV, HBV and/or HCV infections JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - A190 LP - A191 DO - 10.1136/sextrans-2019-sti.481 VL - 95 IS - Suppl 1 AU - Maryam Darvishian AU - Carmine Rossi AU - Stanley Wong AU - Amanda Yu AU - Jason Wong AU - Jane Buxton AU - Mark Gilbert AU - Mawuena Binka AU - Zahid Butt AU - Sofia Bartlett AU - Margo Pearce AU - Maria Alvarez AU - Darrel Cook AU - Troy Grennan AU - Ryan Woods AU - John Spinelli AU - Mark Tyndall AU - Mel Krajden AU - Naveed Janjua Y1 - 2019/07/01 UR - http://sti.bmj.com/content/95/Suppl_1/A190.3.abstract N2 - Background HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections each are associated with increased cancer risk. In this study, we assessed the effect of co-occurrence of HIV, HBV and HCV on all cancers, anal cancer, non-Hodgkin Lymphoma (NHL) and liver cancer.Methods We used the British Columbia Hepatitis Testers Cohort (BC-HTC) which includes all individuals (∼1.7 million) tested for HCV or HIV, or diagnosed with HCV, HIV, or HBV linked with data on cancers. We included individuals tested for all three infections since 1990 and followed them from the date of their last test until the first cancer diagnosis, death, or 12/31/2015. We utilized the Fine and Grey competing risks regression model to estimate adjusted sub-distributional hazard ratios (aHRs) for outcomes, with death as a competing risk.Results Among 514,501 individuals tested for all infections, 12,586 had any cancer (2.45%), 100 had anal cancer (0.02%), 552 had NHL (0.11%), and 1,081 had liver cancer (0.21%) during a median follow-up of 4.19 years. Compared to no infection, the aHR for all cancers was the highest for HIV/HBV co-infections (HR 2.55, 95% CI: 1.91–3.42) followed by triple infections (aHR 2.29, 95% CI: 1.80–2.89). The risk of anal cancer was higher among individuals with HIV (triple infection aHR 22.61, 95% CI: 7.27–70.33), while risk of the liver cancer was higher among those with HBV or HCV mono or co-infections and triple infections. The risk of NHL was the highest among HIV/HBV co-infections followed by triple infection.Conclusion HIV, HBV and HCV infections are associated with an overall higher risk of cancer. The highest risks for anal cancer and NHL were among those living with HIV infection. The observed association between HCV and anal cancer, which may be due to the presence of human papillomavirus and/or residual confounding, requires further investigation.Disclosure No significant relationships. ER -