PT  - JOURNAL ARTICLE
AU  - Sinead Delany-Moretlwe
AU  - Nyaradzo Mgodi
AU  - Linda-Gail Bekker
AU  - Jared Baeten
AU  - Subash Pathak
AU  - Deborah Donnell
AU  - Denni Lennon
AU  - Scott Rose
AU  - Keolopile Makgamathe
AU  - Sheetal Kassim
AU  - Shorai Mukaka
AU  - Heather Noble
AU  - Adeola Adeyeye
AU  - Connie Celum
TI  - O10.3 High curable STI prevalence and incidence among young african women initiating PrEP in HPTN 082
AID  - 10.1136/sextrans-2019-sti.160
DP  - 2019 Jul 01
TA  - Sexually Transmitted Infections
PG  - A60--A61
VI  - 95
IP  - Suppl 1
4099  - http://sti.bmj.com/content/95/Suppl_1/A60.2.short
4100  - http://sti.bmj.com/content/95/Suppl_1/A60.2.full
SO  - Sex Transm Infect2019 Jul 01; 95
AB  - Background African women face overlapping HIV and STI risks. PrEP programs among men who have sex with men have seen high STI incidence, but few data from African women taking PrEP are availableMethods HPTN 082 was conducted in Cape Town, Johannesburg (South Africa) and Harare (Zimbabwe) to evaluate uptake and adherence to daily oral PrEP in young African women. Sexually active HIV-negative women ages 16–25 were enrolled. Enrollment vaginal swabs were tested for gonorrhea (GC) and chlamydia (CT) by nucleic acid amplification, and trichomonas (TV) by rapid test. Syphilis serology was assessed. All women with positive test results received treatment. Repeat testing was conducted at 6 and 12 months.Results Of the 412 women who initiated PrEP, median age was 21 years, 84% reported a primary sex partner and a median of 4 vaginal sex acts (IQR 2,8) in the prior month; 35% reported that they never or rarely used condoms. At enrollment 29% of women had CT, 8% GC, 7% TV and 2% reactive syphilis serology. STI incidence was 29.6 per 100 person-years (py) for CT (95% CI 24.3, 35.4), 11.8 per 100 py for GC (95% CI 8.7, 15.7), and 7.1 per 100 py for TV (95% CI 4.7, 10.2). The majority of incident STIs were new infections: 79 of 119 CT infections, 41 of 48 GC infections, and 23 of 29 TV infections diagnosed were in women who did not have these infections at enrollment. The majority of these infections were asymptomatic.Conclusion The prevalence and incidence of treatable STIs were high among young African women initiating PrEP. Diagnostic STI testing is important and innovative strategies that reduce STI acquisition, complications, and their potential impact on future fertility, need evaluation within the context of PrEP services where currently syndromic STI management is the standard of care.Disclosure No significant relationships.