PT  - JOURNAL ARTICLE
AU  - Ang, Li Wei
AU  - Wong, Chen Seong
AU  - Ng, Oon Tek
AU  - Leo, Yee Sin
TI  - Incidence of syphilis among HIV-infected men in Singapore, 2006–2017: temporal trends and associated risk factors
AID  - 10.1136/sextrans-2019-054163
DP  - 2020 Jun 01
TA  - Sexually Transmitted Infections
PG  - 293--299
VI  - 96
IP  - 4
4099  - http://sti.bmj.com/content/96/4/293.short
4100  - http://sti.bmj.com/content/96/4/293.full
SO  - Sex Transm Infect2020 Jun 01; 96
AB  - Objective There have been recent reports globally on substantial increase in syphilis diagnoses particularly among high-risk men. The aim of this study was to assess temporal trends of incident syphilis and associated risk factors among HIV-infected men in Singapore.Methods We conducted retrospective cohort analysis using the clinical database maintained by the Clinical HIV Programme at the National Centre for Infectious Diseases, Singapore. HIV-infected men with a negative syphilis result at baseline who had undergone at least one subsequent test in 2006–2017 were included. Factors associated with incident syphilis were investigated using Cox proportional hazards regression analyses.Results A total of 1069 HIV-infected men were tested for syphilis at least once following their negative baseline test during the 12-year period, and they contributed 4284 person-years of follow-up (PYFU). There were 266 cases of incident syphilis, giving an overall incidence of 6.21 per 100 PYFU (95% CI 5.49–7.00). The incidence of syphilis per 100 PYFU increased from 1.21 (95% CI 0.33 to 3.10) in 2010 to 26.04 (95% CI 19.97 to 33.40) in 2017. In the multivariable model, risk factors for syphilis seroconversion were: age 15–24 years at HIV diagnosis (adjusted HR (aHR) 1.64, 95% CI 1.05 to 2.56) versus ≥45 years, being Chinese (aHR 1.82, 95% CI 1.01 to 3.29) versus Indian and other minority ethnic groups, men having sex with men (MSM) (aHR 3.29, 95% CI 2.22 to 4.87) versus heterosexuals, and HIV diagnosis in later periods of 2009–2011 (aHR 1.96, 95% CI 1.41 to 2.74), 2012–2014 (aHR 3.96, 95% CI 2.68 to 5.83) and 2015–2017 (aHR 7.94, 95% CI 4.52 to 13.95) versus 2006–2008.Conclusion The annual incidence rate of syphilis in HIV-infected men was on the rise, and it was consistently higher among MSM than in heterosexual men. The findings supported regular screening for syphilis and enhanced behavioural interventions in Singapore.