TY - JOUR T1 - STI perspectives JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 393 LP - 394 DO - 10.1136/sextrans-2019-054274 VL - 96 IS - 6 AU - Giovanni Villa AU - Sarah K Edwards AU - Rayner Kay Jin Tan Y1 - 2020/09/01 UR - http://sti.bmj.com/content/96/6/393.abstract N2 - Mycoplasma genitalium is an aetiological agent of sexually transmitted urethritis. A cohort study investigated M. genitalium prevalence, antibiotic resistance and association with previous macrolide exposure among 1816 Chinese men who presented with symptomatic urethritis between 2011 and 2015. Infection was diagnosed by PCR, and sequencing was used to detect mutations that confer resistance to macrolides and fluoroquinolones. In 11% of men, M. genitalium was the sole pathogen identified. Nearly 90% of infections were resistant to macrolides and fluoroquinolones; previous macrolide exposure was associated with higher prevalence of resistance (97%). The findings point to the need for routine screening for M. genitalium in symptomatic men with urethritis. Treatment strategies to overcome antibiotic resistance in M. genitalium are needed.Yang L, Xiaohong S, Wenjing L, et al. Mycoplasma genitalium in symptomatic male urethritis: macrolide use is associated with increased resistance. Clin Infect Dis 2020;5:805–10. doi:10.1093/cid/ciz294.Fostemsavir, the prodrug of temsavir, is an attachment inhibitor: by targeting the gp120 protein on the HIV-1 envelope, it prevents viral interaction with the CD4 receptor. No cross-resistance has been described with other antiretroviral agents, including those that target viral entry by other modalities. In the phase III BRIGHTE trial, 371 highly treatment-experienced patients who … ER -