RT Journal Article SR Electronic T1 Macrolide and fluoroquinolone resistance of Mycoplasma genitalium in southern Spain, 2018–2019 JF Sexually Transmitted Infections JO Sex Transm Infect FD BMJ Publishing Group Ltd SP 8 OP 10 DO 10.1136/sextrans-2019-054386 VO 97 IS 1 A1 Adolfo de Salazar A1 Antonio Barrientos-Durán A1 Beatriz Espadafor A1 Ana Fuentes-López A1 Natalia Chueca A1 Federico Garcia YR 2021 UL http://sti.bmj.com/content/97/1/8.abstract AB Objectives In recent years, resistance in Mycoplasma genitalium (MG) to first-line (azithromycin) and second-line (moxifloxacin) treatment has been increasingly reported worldwide, however, no data regarding the south of Spain are available.Methods To determine resistance rates, MG-positive samples collected from June 2018 to June 2019 were analysed by sequencing the 23S rRNA and parC genes.Results A total of 77 patients (24 men having sex with men (MSM), 30 heterosexual men and 23 women) were included. Resistance-associated mutations against macrolide and fluoroquinolones were found in 36.4% (95% CI 25.7% to 48.1%) and 9.1% (95% CI 3.7% to 17.8%) of the patients, respectively. Being MSM and having had another STI in the last year were significantly associated with macrolide-resistant MG infection, while no associations were found with resistance to fluoroquinolones.Conclusions Testing for resistance to first-line and second-line drugs against MG should be recommended for the general population and mandatory for the MSM population. We suggest that empiric azithromycin use for STI management should be avoided.