PT - JOURNAL ARTICLE AU - Daniel Richardson AU - Alice Pickering AU - Kayleigh Nichols AU - Zoe Buss AU - Daniel Trotman AU - Colin Fitzpatrick AU - Deborah Williams TI - Factors associated with testing positive for syphilis among MSM who present as sexual contacts of syphilis from a clinic-based population AID - 10.1136/sextrans-2020-054878 DP - 2021 Apr 19 TA - Sexually Transmitted Infections PG - sextrans-2020-054878 4099 - http://sti.bmj.com/content/early/2021/04/18/sextrans-2020-054878.short 4100 - http://sti.bmj.com/content/early/2021/04/18/sextrans-2020-054878.full AB - Objectives There has been a significant increase in syphilis in men who have sex with men (MSM) in the UK over the past 20 years. Partner notification strategies have increased the number of MSM attending STI clinics as sexual contacts of syphilis. Current guidelines suggest testing and consideration of presumptive antimicrobial treatment. Syphilis treatment with benzathine penicillin requires clinic resources, is painful and is associated with complications. It is important we consider strategies to rationalise presumptive antimicrobial use and promote antimicrobial stewardship.Methods We aimed to determine if there are any factors associated with having syphilis among MSM attending as sexual contacts of syphilis in a cross-sectional study. We examined the clinical records of MSM attending as sexual contacts of syphilis from January to December 2019.Results Of the 6613 MSM who attended for STI testing, 142 of 6613 (2.1%) presented as sexual contacts of syphilis. The median age was 40 years (IQR=31–51), 43 of 142 (30%) were HIV positive, 38 of 142 (27%) had been diagnosed and treated for syphilis in the past, and 11 of 142 (8%) presented with symptoms (possible lesions of primary or secondary syphilis). Thirteen (9%, 95% CI=4.4 to 13.9) tested positive for syphilis on the day of presentation. MSM who were symptomatic (genital ulcer or body rash), HIV positive or had a history of syphilis were significantly more likely to test positive for syphilis (OR=51.88, 95% CI: 3.01 to 893.14, p=0.007).Conclusions We have shown that in our clinic-based population of MSM who presented as sexual contacts of syphilis, the factors associated with testing positive for syphilis were: having HIV, having a history of syphilis or presenting with symptoms (possible lesions of primary or secondary syphilis). These factors could be used to rationalise antibiotic treatment among MSM presenting as sexual contacts of syphilis. Further research is needed to validate this finding in other populations of MSM and people affected by syphilis.