TY - JOUR T1 - Research news in clinical context JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 395 LP - 396 DO - 10.1136/sextrans-2020-054858 VL - 97 IS - 6 AU - Miguel Fernández-Huerta AU - Danielle Solomon AU - Rayner Kay Jin Tan Y1 - 2021/09/01 UR - http://sti.bmj.com/content/97/6/395.abstract N2 - Ceftriaxone monotherapy is well established for treating Neisseria gonorrhoeae (NG) urethritis, but data are limited for pharyngeal and rectal infections. This prospective single-centre study was conducted in Japan in 2017–2020 among HIV-negative men who have sex with men (MSM) who underwent routine STI screening, including nucleic acid amplification tests (NAATs) for rectal and pharyngeal NG every 3 months.1 Among 320 cases of extragenital gonorrhoea (all asymptomatic), 208 received only ceftriaxone (single 1 g intravenous dose) and 112 received additional treatment with doxycycline (100 mg two times a day for 7 days) or azithromycin (single 1 g dose) for concomitant STIs (predominantly, Chlamydia trachomatis (CT)). There was no difference in NG cure rates between the two groups (98.1% vs 95.5%) or by infection site. Data are needed for other ceftriaxone dosing strategies and in areas where ceftriaxone resistance is a major concern.This systematic review and meta-analysis compiled data from 30 studies that reported NG testing during pregnancy and compared pregnancy and birth outcomes between … ER -