%0 Journal Article %A Valentina Isernia %A Bao Phung %A Annie Marie Lepretre %A Bahar Azadi %A Giovanna Rincon %A Julia Zelie %A Sylvie Le Gac %A Andres Deprez %A Florence Michard %A Yazdan Yazdanpanah %A Jade Ghosn %T Pre-exposure HIV prophylaxis (PrEP) among transgender women: 3 years of follow-up in a university hospital in Paris %D 2021 %R 10.1136/sextrans-2020-054618 %J Sexually Transmitted Infections %P 465-466 %V 97 %N 6 %X Objectives The principal outcome was to describe clinical characteristics of a transgender male-to-female (TGW) cohort followed for pre-exposure HIV prophylaxis (PrEP).Introduction Few efforts and preventive interventions have targeted transgender population, despite them being at great risk of HIV infection.Methods This was a retrospective transgender male-to-female (TGW) cohort followed for PrEP at Bichat Hospital Sexual Health Clinic between February 2016 and January 2019.The principal outcome was to describe clinical characteristics of this TGW population: modalities of PrEP uptake, treatment adherence and tolerance, sanitary system retention, hormonal therapy and STIs.Data about age, ethnicity, language, sex work and sanitary healthcare insurance coverage were also collected.Results Forty-nine TGW were included, with a median age of 33 years; 43/49 (87.7%) were from South America and 43/49 (87.7%) were sex workers. Forty-four 44/49 TGW (89.7%) had no regular healthcare insurance coverage. Nineteen out of 49 (38.7%) had a history of STI in the last 12 months. Hormone intake was reported in 16/49 (32.60%). PrEP with oral TDF/FTC was prescribed on a daily basis for 45/49 TG (91.8%). Two TGW discontinued PrEP for gastrointestinal intolerance. No case of renal toxicity or HIV seroconversion has been reported. Retention rate was high (71.4%), but average follow-up was 9 months.Conclusions Our data showed a very vulnerable population, with a high proportion of migrants, sex workers and with a low healthcare insurance coverage. Retention rate was high (71.4%). Further multi-component interventions are needed to improve global sex health approach, PreP follow-up and sanitary system retention among TGW population. %U https://sti.bmj.com/content/sextrans/97/6/465.full.pdf