RT Journal Article SR Electronic T1 The clinical indications for testing women for Mycoplasma genitalium JF Sexually Transmitted Infections JO Sex Transm Infect FD BMJ Publishing Group Ltd SP 277 OP 285 DO 10.1136/sextrans-2020-054818 VO 98 IS 4 A1 Latimer, Rosie L A1 Vodstrcil, Lenka A A1 Plummer, Erica L A1 Doyle, Michelle A1 Murray, Gerald L A1 Fairley, Christopher K A1 Bodiyabadu, Kaveesha A1 Read, Tim R H A1 Kaiser, Marti A1 Mokany, Elisa A1 Guy, Rebecca A1 Chow, Eric P F A1 Bradshaw, Catriona YR 2022 UL http://sti.bmj.com/content/98/4/277.abstract AB Background While the contribution of Mycoplasma genitalium (MG) to symptoms in men is well described, less is known about its association with common genital symptoms in women. We aimed to determine the prevalence of MG and macrolide resistance, and its association with common genital symptoms in women attending a sexual health service, to inform indications for testing and clinical practice.Methods We undertook a cross-sectional study of symptomatic and asymptomatic women attending Melbourne Sexual Health Centre (MSHC), between April 2017 and April 2019. Women were tested for MG and macrolide resistance, Chlamydia trachomatis (CT), Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis and vulvovaginal candidiasis. Women completed a questionnaire on symptoms, and symptomatic women underwent examination. The prevalence of MG (and macrolide resistance) and other genital infections was calculated with 95% CIs, and associations between these outcomes and specific genital symptoms were examined using logistic regression.Results Of 1318 women, 83 (6%, 95% CI: 5% to 8%) had MG, of which 39 (48%, 95% CI: 36% to 59%) had macrolide-resistant MG; 103 (8%, 95% CI: 6% to 9%) women had CT. MG prevalence was similar in asymptomatic (10 of 195; 5%) and symptomatic (73 of 1108; 7%) women, p=0.506. MG was associated with mucopurulent cervicitis on examination (adjusted OR=4.38, 95% CI: 1.69 to 11.33, p=0.002), but was not associated with other specific genital symptoms or signs.Conclusions MG was as common as CT among women attending MSHC. MG was not associated with genital symptoms, but like CT, was significantly associated with cervicitis. These data provide evidence that routine testing for MG in women with common genital symptoms is not indicated. The presence of macrolide resistance in 48% of women supports use of resistance-guided therapy.No data are available. Data generated are confidential as they relate to patients at MSHC.