TY - JOUR T1 - Association between rectal gonorrhoea and HIV incidence in men who have sex with men: a meta-analysis JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 492 LP - 496 DO - 10.1136/sextrans-2021-055254 VL - 98 IS - 7 AU - Deborah Donnell AU - Kidist Zewdie AU - Natasha Ratna AU - Veronica Miller AU - John Michael Saunders AU - O Noel Gill AU - Valerie Delpech AU - Hamish Mohammed Y1 - 2022/11/01 UR - http://sti.bmj.com/content/98/7/492.abstract N2 - Background Incidence of rectal gonorrhoea (GC) has been hypothesised as a correlate of HIV exposure in prevention trials of men who have sex with men (MSM). High rectal GC incidence in MSM trials of new biomedical prevention drugs may provide supportive evidence for ongoing HIV risk. Empirical evidence of correlation between rectal GC and HIV incidence is needed to assess whether high rectal GC rates reliably correlate with high risk of HIV.Methods Rectal GC and HIV are routinely tested in sexual health clinics (SHCs) throughout England. Through routine surveillance data collected at visits to SHCs, we assessed HIV incidence and new rectal GC diagnoses in repeat visits by HIV-negative MSM between 2011 and 2018, predating widespread roll-out of pre-exposure prophylaxis. Meta-analysis regression assessed population-level association between HIV and rectal GC incidence over time.Findings Between 2011 and 2018, HIV and rectal GC incidence was assessed in 541 056 HIV-negative MSM attending SHCs in England. HIV incidence among MSM attending SHCs fell from 1.26/100 person-years (PYs) in 2011 to 0.28/100 PYs in 2018. Rectal GC rates increased from 3.5/100 PYs to 11.1/100 PYs over the same period. The rate of HIV incidence decreased by 22.3% for each percent increase in rectal GC (95% CI –30.8 to –14.7, p<0.001).Interpretation Among the population of MSM attending SHCs in England, rectal GC rates increased substantially while HIV incidence rates decreased between 2011 and 2018. HIV incidence likely decreased through expanded HIV testing, prompt antiretroviral treatment (ART) initiation and increased viral suppression in persons living with HIV, interventions that did not decrease rectal GC. Rectal GC may not be an ideal proxy for HIV incidence in trials, as HIV exposure risk is complex and context dependent, given effective HIV prevention interventions in MSM.IntroductionAll data relevant to the study are included in the article or uploaded as supplemental information. Not applicable. ER -