Clinical features, results of CSF brain protein detection, and outcome in patients with lymphoma
| CSF | |||||
|---|---|---|---|---|---|
| Patient | Type of lymphoma | No of lumbar puncture | Interval between lumbar puncture (weeks) | 14-3-3 detection | Outcome |
| CNS = central nervous system. NA = not applicable. EBV = Epstein–Barr virus. CSF = cerebrospinal fluid. MR = magnetic resonance. RT = radiotherapy. HAART = highly active antiretroviral therapy. | |||||
| 1 | Primary CNS | 1 | No | Died 2 weeks after second lumbar puncture | |
| 11 | Necropsy showed also cerebral toxoplasmosis | ||||
| 2 | Yes | ||||
| 2 | Primary CNS | 1 | No | Died 2 weeks after second lumbar puncture | |
| 3 | Necropsy confirmed diagnosis | ||||
| 2 | No | ||||
| 3 | Primary CNS | 1 | NA | No | Died 3 weeks later. No necropsy |
| 4 | Systemic, disseminated extraneural | 1 | NA | Yes | Died 6 weeks later. Cranial MR scan normal but EBV DNA detected in cell free CSF |
| No necropsy | |||||
| 5 | Systemic, extra neural | 1 | NA | Yes | Alive. Cranial MR scan normal. Treated with local RT and HAART. No lymphoma recurrence after 39 months follow up |