Susceptibility to ciprofloxacin of Neisseria gonorrhoeae isolated in India and the number of GyrA and ParC alterations
| No of mutations in | ||||||
|---|---|---|---|---|---|---|
| Name of isolates | No of isolates | % isolates | MIC* (μg/ml) of ciprofloxacin | gyrA | parC | |
| *Based on MICs (minimum inhibitory concentrations), isolates were labelled as susceptible (S), intermediate resistant (IR), and resistant (R).20 | ||||||
| Clinical isolates | ||||||
| UD1–UD5 | 5 | 8% | <0.06 | (S) | No mutation | No mutation |
| UD6 | 1 | 1% | 0.1 | (IR) | One | No mutation |
| UD7–UD9 | 3 | 5% | 0.25 | (IR) | Two | One (silent) |
| UD10–UD13 | 4 | 6% | 0.38 | (IR) | Two | One (silent) |
| UD14–UD21 | 8 | 13% | 0.50 | (IR) | Two | One (silent) |
| UD22–UD28 | 7 | 11% | 0.75 | (IR) | Two | Two (silent) |
| UD29–UD32 | 4 | 6% | 1.0 | (R) | Two | One |
| UD33–UD40 | 8 | 13% | 1.5 | (R) | Two | One |
| UD41–UD44 | 4 | 6% | 2.0 | (R) | Two | One |
| UD45, UD46 | 2 | 3% | 3.0 | (R) | Two | One |
| UD47–UD50 | 4 | 6% | 4.0 | (R) | Two | One |
| UD51 | 1 | 1% | 12.0 | (R) | Two | Two (one silent) |
| UD52–UD61 | 10 | 16% | 32.0 | (R) | Two | Two (one silent) |
| UD62, UD63 | 2 | 3% | 32.0 | (R) | Three | Three (two silent) |
| WHO reference strains: | ||||||
| WHO strain A | 1 | – | 0.016 | (S) | No mutation | No mutation |
| WHO strain H | 1 | – | 2.0 | (R) | Two | One |
| WHO strain J | 1 | – | 8.0 | (R) | Two | One |