Table 2

Mutation patterns in the GyrA and ParC proteins of Neisseria gonorrhoeae isolates

Sequence change(s) in
GyrA*ParC*
Name of isolatesSer-91 (TCC)Asp-95 (GAC)Val-120 (GTG)Glu-91 (GAG)Phe-100 (TTT)Tyr-104 (TAT)Gly-109 (GGC)Leu-131 (CTC)
UD1–UD5†Ser-91 (TCC)Asp-95 (GAC)Val-120 (GTG)Glu-91 (GAG)Phe-100 (TTT)Tyr-104 (TAT)Gly-109 (GGC)Leu-131 (CTC)
*Associated codon is indicated in the parenthesis; †and –, identical to wild type.
UD6Phe-91 (TTC)
UD7–UD9Phe-91 (TTC)Asn-95 (AAC)Leu-131 (CTG)
UD10–UD21Phe-91 (TTC)Asn-95 (AAC)Tyr-104 (TAC)
UD22–UD28Phe-91 (TTC)Asn-95 (AAC)Tyr-104 (TAC)Leu-131 (CTG)
UD29–UD50Phe-91 (TTC)Asn-95 (AAC)Gly-91 (GGG)
UD51Phe-91 (TTC)Asn-95 (AAC)Gly-91 (GGG)Tyr-104 (TAC)
UD52–UD61Phe-91 (TTC)Gly-95 (GGC)Gly-91 (GGG)Leu-131 (CTG)
UD62, UD63Phe-91 (TTC)Asn-95 (AAC)Leu-120 (TTG)Tyr-100 (TAT)Tyr-104 (TAC)Gly-109 (GGG)