Treatment guidelines for acquired syphilis during pregnancy 62
| Stage of infection | Regimen |
|---|---|
| Primary | Benzathine penicillin G, 2.4 million units intramuscularly × 1 |
| Secondary | |
| Early latent (<1 year) | |
| Late latent (>1 year) | Benzathine penicillin G, 2.4 million units intramuscularly weekly × 3 |
| Unknown duration | |
| Neurosyphilis | Aqueous penicillin G, 2–4 million units intramuscularly every 4 hours × 10–14 days |
| or | |
| Procaine penicillin G 2.4 million units intramuscularly and probenecid 500 mg by mouth four times daily × 10–14 days |