Pharmacokinetic assumptions for compounds reviewed
| Parameter | Cefuroxime oral | Cefuroxime intramuscular | Ceftriaxone intramuscular | Cefixime oral |
|---|---|---|---|---|
| V1, volume of distribution (l) | 24.2 | 12.0 | 14.7 | 19.0 |
| k10, elimination rate (h−1) | 0.55 | 0.53 | 0.082 | 0.204 |
| Fu, unbound fraction | 0.67 | 0.67 | 0.05 | 0.35 |
| F, bioavailibility | 0.8 | 1.00 | 1.00 | 0.5 |
| ka, absorbtion constant (h−1) | 0.82 | 1.00 | 1.00 | 0.55 |
| t½, half life (h) | 1.25 | 1.31 | 8.45 | 3.40 |
| References | 11–13 | 11–13 | 14, 15 | 16 |