Test of cure (TOC) | | | | |
Clinical resolution | 286 (75.7%) | 300 (82.6%) | 248 (90.2%) | 262 (90.7%) |
Clinical failure or <70% improvement | 46 (12.2%) | 41 (11.3%) | 27 (9.8%) | 27 (9.3%) |
Indeterminate/missing* | 46 (12.2%) | 22 (6.1%) | 0 | 0 |
Treatment difference (95% CI) | | |
Indeterminates/missing considered non-successes | −6.9% (−12.3% to −0.9%) | −0.5% (−5.7% to 4.0%) |
Indeterminates/missing excluded | −1.8% (−6.9% to 3.2%) | |
Follow up | | | | |
Continued resolution | 284 (75.1%) | 294 (81.0%) | 236 (85.8%) | 254 (87.9%) |
Clinical relapse | 12 (3.2%) | 15 (4.1%) | 10 (3.6%) | 11 (3.8%) |
Failures carried forward from TOC† | 36 (9.5%) | 22 (6.1%) | 22 (8.0%) | 16 (5.5%) |
Indeterminate/missing* | 46 (12.2%) | 32 (8.8%) | 7 (2.5%) | 8 (2.8%) |
Treatment difference (95% CI) | | |
Indeterminates/missing considered non-successes | −5.9% (−11.5% to 0.3%) | −2.1% (−8.0% to 3.1%) |
Indeterminates/missing excluded | −3.3% (−8.3% to 1.8%) | −2.3 (−7.8% to 2.6%) |