Table 4

Performance of rapid diagnostic tests for syphilis in round 1

Sites	Determine Syphilis TP Abbott Labs		Syphilis Fast Diesse Diagnostica		Espline TP Fujirebio Inc		Syphicheck-WB Qualpro Diagnostics		SD Bioline Syphilis 3.0 Standard Diagnostics		Visitect Syphilis Omega Diagnostics
Sites	Sens (%)	Spec (%)	Sens (%)	Spec (%)	Sens (%)	Spec (%)	Sens (%)	Spec (%)	Sens (%)	Spec (%)	Sens (%)	Spec (%)
*The Breslow-Day test for homogeneity of odds ratios was calculated to determine the extent of site-to-site variation of test performance.
†The κ value for each test is a summation of the overall performance of each test against the reference standard for all sites. A value of 0.75 or greater is considered excellent.
CI, confidence interval; Sens, sensitivity; Spec, specificity.
Moscow, Russian Fed.	100	100	72	98	100	83	80	100	92	98	76	100
Birmingham, USA	88	92	57	92	98	88	82	94	94	90	80	94
Port au Prince, Haiti	100	98	100	92	98	100	90	98	100	100	90	100
Nanjing, China	98	93	79	89	94	93	77	95	89	96	81	93
Mwanza, Tanzania	96	94	94	90	98	100	80	100	94	94	82	100
Colombo, Sri Lanka	100	98	96	100	98	96	88	100	96	100	92	100
Durban, South Africa	96	90	94	96	96	94	82	100	94	98	86	100
Fajara, The Gambia	100	88	94	86	100	92	96	94	100	84	92	96
Overall results	97.2	94.1	86	92.8	97.7	93.4	84.5	97.7	95	94.9	85	98
95% CIs	95.6 to 98.8	91.8 to 96.4	82.5 to 89.4	90.3 to 95.4	96.3 to 99.2	90.9 to 95.8	80.9 to 88.0	96.2 to 99.2	92.8 to 97.1	92.7 to 97.1	81.4 to 88.5	96.5 to 99.4
Homogeneity* p values	0.0086		0.0002		0.2529		0.1427		0.1132		0.03
κ† (95% CI)	0.95 (0.93 to 0.97)		0.87 (0.84 to 0.90)		0.95 (0.93 to 0.97)		0.84 (0.80 to 0.87)		0.9 (0.87 to 0.94)		0.85 (0.82 to 0.89)