Table 1

Accuracy measures for the Abbott Determine Syphilis TP test and hospital RPR

		Gold standard*		Sensitivity (%) (95% CI§)	Specificity (%) (95% CI)	Positive predictive value (%) (95% CI)	Negative predictive value (%) (95% CI)
		True positive n = 342	True negative n = 8550	Sensitivity (%) (95% CI§)	Specificity (%) (95% CI)	Positive predictive value (%) (95% CI)	Negative predictive value (%) (95% CI)
Gold standard definition of a syphilis case: positive rapid plasma reagin (RPR) performed by the reference laboratory confirmed by positive Treponema pallidum* particle agglutination assay (TPPA) performed by the same laboratory.
†Specimens for 8 participants were not available (lost or insufficient volume) for testing at the reference laboratory.
‡Three additional specimens were not available for testing by RPR in the hospital.
§Exact binomial confidence intervals.
Determine Syphilis TP†	+	314	128	91.8 (88.4 to 94.5)	98.5 (98.2 to 98.8)	71.0 (66.6 to 75.2)	99.7 (99.5 to 99.8)
Determine Syphilis TP†	−	28	8422	91.8 (88.4 to 94.5)	98.5 (98.2 to 98.8)	71.0 (66.6 to 75.2)	99.7 (99.5 to 99.8)
Hospital RPR‡	+	259	78	75.7 (70.8 to 80.2)	99.0 (98.9 to 99.3)	76.9 (72.0 to 81.3)	99.0 (98.8 to 99.2)
Hospital RPR‡	−	83	8469	75.7 (70.8 to 80.2)	99.0 (98.9 to 99.3)	76.9 (72.0 to 81.3)	99.0 (98.8 to 99.2)