| No who did not report missing tablets at visit no | Acyclovir | Placebo |
| 1 | 48/56 (86) | 42/46 (91) |
| 2 | 51/59 (86) | 41/43 (95) |
| 3 | 49/53 (92) | 41/45 (91) |
| 4 | 49/51 (96) | 39/41 (95) |
| 5 | 50/54 (93) | 36/41 (88) |
| 6 | 44/47 (94) | 34/35 (97) |
| 7 | 48/52 (92) | 36/37 (97) |
| 8 | 46/50 (92) | 31/34 (91) |
| 9 | 43/47 (91) | 38/41 (93) |
| 10 | 44/50 (88) | 39/45 (87) |
| 11 | 40/46 (87) | 33/41 (80) |
| 12 | 45/49 (92) | 35/40 (87) |
| Overall | 557/614 (91) | 445/489 (91) |
| Visit number | Proportion adherent* (%) | Proportion adherent* (%) |
| 1 | 43/56 (77) | 39/47 (83) |
| 2 | 43/60 (60) | 36/44 (82) |
| 3 | 45/54 (83) | 41/49 (84) |
| 4 | 44/53 (83) | 36/44 (82) |
| 5 | 42/51 (82) | 33/41 (80) |
| 6 | 40/50 (80) | 25/39 (64) |
| 7 | 39/52 (75) | 29/44 (66) |
| 8 | 39/51 (76) | 25/37 (68) |
| 9 | 38/48 (79) | 24/40 (60) |
| 10 | 34/51 (67) | 28/42 (67) |
| 11 | 32/47 (68) | 25/43 (58) |
| 12 | 25/48 (52) | 23/40 (58) |
| Overall adherence | 464/621 (74) | 364/510 (71) |
*Participants were defined as adherent if they returned within ±5 pills of the expected number of tablets at each weekly visit. The number who returned with 5 pills more than expected, returned with ±5 pills (ie, adherent) or who returned with 5 pills less than expected over all 1131 patient visits was as follows.