Poisson regressions for shedding and lesions
| Genital shedding | Oral shedding | |||
| RR (95% CI) | p Value | RR (95% CI) | p Value | |
| Any APOE4 versus none | 0.94 (0.68 to 1.29) | 0.69 | 1.65 (0.69 to 3.97) | 0.26 |
| Any APOE4 versus none* | 0.93 (0.68 to 1.29) | 0.68 | 1.61 (0.68 to 3.79) | 0.28 |
| Male gender | 0.87 (0.64 to 1.18) | 0.37 | 1.41 (0.58 to 3.46) | 0.45 |
| HSV-1 and HSV-2 infection | 1.23 (0.91 to 1.67) | 0.17 | 3.35 (0.52 to 21.77) | 0.21 |
| Genital lesions | oral lesions | |||
| RR (95% CI*) | p Value | RR (95% CI*) | p Value | |
| Any APOE4 versus none | 0.93 (0.61 to 1.41) | 0.72 | 4.64 (1.32 to 15.05) | 0.016 |
| Any APOE4 versus none* | 0.86 (0.57 to 1.29) | 0.45 | 4.04 (1.09 to 15.01) | 0.037 |
| Male gender | 1.02 (0.69 to 1.52) | 0.91 | 1.57 (0.37 to 6.59) | 0.54 |
| HSV-1 and HSV-2 infection | 1.08 (0.73 to 1.60) | 0.70 | 0.74 (0.16 to 3.39) | 0.70 |
| History of genital herpes | 5.13 (2.20 to 11.98) | <0.001 | — | — |
↵* Relative risk (RR) adjusted for gender, co-infection, time since infection and symptoms at site. Dataset on oral symptoms is incomplete so no adjustment is made for oral shedding.
HSV, herpex simplex virus.