Country | First line† | Second line† | Alternative treatments† |
Armenia | Ceftriaxone 250 mg, IM×1 | Ofloxacin 400 mg, PO×1 | Cefixime 400 mg, PO×1 |
Azerbaijan | Ceftriaxone 1 g, IM×1 | Spectinomycin 2 g, IM×1 | |
Belarus | Ceftriaxone 1 g, IM×1 | Spectinomycin 2 g (men), 4 g (women), IM×1 | Azithromycin 1 g, PO×1; Doxycycline 100 mg, PO twice a day for 7 days |
Estonia | Ceftriaxone 250 mg, IM×1 | Ciprofloxacin 500 mg, PO×1 | Ofloxacin 400 mg, PO×1 |
Georgia | Ceftriaxone 250 mg, IM×1 | Azithromycin 1 g, PO×1 | Doxycycline 100 mg, PO twice a day for 7 days |
Kazakhstan | Ceftriaxone 250 mg, IM×1 | Spectinomycin 2 g, IM×1 | |
Kyrgyzstan | Ceftriaxone 250 mg, IM×1 | Spectinomycin 2 g, IM×1 | Ciprofloxacin 500, PO×1 |
Russia | Ceftriaxone 250 mg, IM×1 | Spectinomycin 2 g, IM×1 | |
Tajikistan | Ceftriaxone 250 mg, IM×1 | Spectinomycin 2 g, IM×1 | Azithromycin 1 g, PO×1 |
Ukraine | Ceftriaxone 500 mg, IM×1 | Cefixime 400 mg, PO×1 | Spectinomycin 2 g, IM×1; Kanamycin 2 g, IM×1 |
Uzbekistan | Ceftriaxone 250 mg, IM×1 | Roxithromycin 150 mg, PO twice a day for 7 days | Doxycycline 100 mg, PO twice a day for 5 days; Azithromycin 1 g, PO×1; Kanamycin 2 g, IM×1; Erythromycin 500 mg, PO 4 times a day for 7–14 days (for pregnant women) |
IM, injected intramuscularly; PO, per os.
↵* All countries belong to the WHO Euro region, are independent countries of the former Soviet Union and are members of the EE SRH Network.11 However, geographically, they represent East European countries (Belarus, Estonia, Russia, Ukraine), Caucasian countries (Armenia, Azerbaijan, Georgia) and Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan, Uzbekistan).
↵† Manufacturer (country) of the antimicrobials used: ceftriaxone: Hoffman La Roche (Switzerland), World Medicine, Pliva Pharma, Mili Healthcare (UK), Medochemie (Cyprus), Pharmacare (Israel), Mustafa Nevzat Ilac Sanayii (Turkey), Lek (Slovenia), Polfa (Poland), Lekko, Synthesis, Kraspharma, Biosynthesis (Russia), Kievmedpreparat, Darnitsa, Borshchahivskiy Chemical-Pharmaceutical Plant (Ukraine), Belmedpreparat, Belbiopharm (Belarus), Kefar (Kazakhstan), Dzhurabek (Uzbekistan), Square Pharmaceuticals (Bangladesh), Torrent Pharmaceuticals, Orchid Healthcare, Plethico Pharmaceuticals (India); spectinomycin: Pharmacia/Pfizer (Belgium/USA), Medochemie (Cyprus); ciprofloxacin: Bayer Shering Pharma AG (Germany), Ozon (Russia); ofloxacin: Sanofi Aventis (France), KC Pharma (Syria); cefixime: Arpimed (Armenia); azithromycin: Pliva (Croatia), Pharmacare (Israel), Valenta (Russia), Pharmland (Belarus), Santo (Kazakhstan), Unique Pharmaceutical Laboratories (India); roxithromycin: Lek (Slovenia), Nobel Pharmsanoat (Turkey); doxycycline: Astellas Europe (The Netherlands), Belbiopharm (Belarus), Lannacher Heilmittel (Austria), Stada Arzneimittel AG (Germany); kanamycin: Kievmedpreparat (Ukraine), Lvovtechnopharm (Ukraine), Unspecified (Russia and China); erythromycin: Teva Pharmaceutical Industries (Israel), Synthesis (Russia).