Table 1

Recommendations for treatment of uncomplicated gonorrhoea in 11 East European countries*

CountryFirst lineSecond lineAlternative treatments
ArmeniaCeftriaxone 250 mg, IM×1Ofloxacin 400 mg, PO×1Cefixime 400 mg, PO×1
AzerbaijanCeftriaxone 1 g, IM×1Spectinomycin 2 g, IM×1
BelarusCeftriaxone 1 g, IM×1Spectinomycin 2 g (men), 4 g (women), IM×1Azithromycin 1 g, PO×1; Doxycycline 100 mg, PO twice a day for 7 days
EstoniaCeftriaxone 250 mg, IM×1Ciprofloxacin 500 mg, PO×1Ofloxacin 400 mg, PO×1
GeorgiaCeftriaxone 250 mg, IM×1Azithromycin 1 g, PO×1Doxycycline 100 mg, PO twice a day for 7 days
KazakhstanCeftriaxone 250 mg, IM×1Spectinomycin 2 g, IM×1
KyrgyzstanCeftriaxone 250 mg, IM×1Spectinomycin 2 g, IM×1Ciprofloxacin 500, PO×1
RussiaCeftriaxone 250 mg, IM×1Spectinomycin 2 g, IM×1
TajikistanCeftriaxone 250 mg, IM×1Spectinomycin 2 g, IM×1Azithromycin 1 g, PO×1
UkraineCeftriaxone 500 mg, IM×1Cefixime 400 mg, PO×1Spectinomycin 2 g, IM×1; Kanamycin 2 g, IM×1
UzbekistanCeftriaxone 250 mg, IM×1Roxithromycin 150 mg, PO twice a day for 7 daysDoxycycline 100 mg, PO twice a day for 5 days; Azithromycin 1 g, PO×1; Kanamycin 2 g, IM×1; Erythromycin 500 mg, PO 4 times a day for 7–14 days (for pregnant women)
  • IM, injected intramuscularly; PO, per os.

  • * All countries belong to the WHO Euro region, are independent countries of the former Soviet Union and are members of the EE SRH Network.11 However, geographically, they represent East European countries (Belarus, Estonia, Russia, Ukraine), Caucasian countries (Armenia, Azerbaijan, Georgia) and Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan, Uzbekistan).

  • Manufacturer (country) of the antimicrobials used: ceftriaxone: Hoffman La Roche (Switzerland), World Medicine, Pliva Pharma, Mili Healthcare (UK), Medochemie (Cyprus), Pharmacare (Israel), Mustafa Nevzat Ilac Sanayii (Turkey), Lek (Slovenia), Polfa (Poland), Lekko, Synthesis, Kraspharma, Biosynthesis (Russia), Kievmedpreparat, Darnitsa, Borshchahivskiy Chemical-Pharmaceutical Plant (Ukraine), Belmedpreparat, Belbiopharm (Belarus), Kefar (Kazakhstan), Dzhurabek (Uzbekistan), Square Pharmaceuticals (Bangladesh), Torrent Pharmaceuticals, Orchid Healthcare, Plethico Pharmaceuticals (India); spectinomycin: Pharmacia/Pfizer (Belgium/USA), Medochemie (Cyprus); ciprofloxacin: Bayer Shering Pharma AG (Germany), Ozon (Russia); ofloxacin: Sanofi Aventis (France), KC Pharma (Syria); cefixime: Arpimed (Armenia); azithromycin: Pliva (Croatia), Pharmacare (Israel), Valenta (Russia), Pharmland (Belarus), Santo (Kazakhstan), Unique Pharmaceutical Laboratories (India); roxithromycin: Lek (Slovenia), Nobel Pharmsanoat (Turkey); doxycycline: Astellas Europe (The Netherlands), Belbiopharm (Belarus), Lannacher Heilmittel (Austria), Stada Arzneimittel AG (Germany); kanamycin: Kievmedpreparat (Ukraine), Lvovtechnopharm (Ukraine), Unspecified (Russia and China); erythromycin: Teva Pharmaceutical Industries (Israel), Synthesis (Russia).