Table 1

Average attributable fractions due to specific interactions (percentage of annual HIV incidence among FSW due to interactions with HSV-2)

Specific interactionBest fit attributable fraction (95% CI from all fits)
% of HIV incidence among FSW due to specific interaction with HSV-2
All interactions combined35.5 (22.2 to 62.5)
Increased susceptibility and infectivity of HIV in the presence of asymptomatic HSV-2 shedding alone32.4 (20.4 to 59.5)
Increased susceptibility and infectivity of HIV in the presence of symptomatic HSV-2 recurrences alone*3.0 (1.4 to 4.3)
Increased susceptibility to HIV among HSV-2-infected FSW24.6 (11.2 to 46.7)
Increased infectivity of HIV from co-infected clients*10.4 (2.3 to 32.5)
  • * Includes implicitly the static effect on HIV transmission of the increased herpes simplex virus type 2 (HSV-2) symptomatic recurrence rate among co-infected clients.

  • FSW, female sex worker.