Elements of Option A regimen reported in each study
| Interventions offered in SWEN,36 PEPI,40 BANS41 and HPTN 04642 | 2010 WHO Option A for breastfeeding communities | |
|---|---|---|
| Antenatal ARVs to pregnant HIV-infected women | Generally single dose NVP to mother | AZT during pregnancy + sdNVP during labour + |
| Some mothers also started on lifelong treatment | AZT/3TC from start of labour until 7 days after | |
| Time when ARVs started antenatally | Onset of labour | AZT from 14 weeks |
| Maternal CD4 count | Included women with CD4 counts as low as 200 cells/ml | Only for women with CD4 <350 cells/ml |
| ARV intervention to infants to prevent peripartum transmission | sdNVP after delivery | NVP daily for 6 weeks |
| ARV intervention to infants to prevent postnatal transmission | Nevirapine to infants while breast feeding (6 weeks, 14 weeks or 6 months) | Nevirapine to infants until 1 month after end of all breast feeding |
3TC, lamivudine; ARV, antiretroviral drug.