Trichomonas and HIV acquisition
| Author | Study design | Country | Testing method | Sample | Main finding | |||
|---|---|---|---|---|---|---|---|---|
| Laga et al18 | Nested case-control* | Democratic Republic of Congo | Wet prep | 431 HIV- women | TV+ women more likely to seroconvert (OR 1.9 95% CI 0.9 to 4.1) | |||
| Laga et al19 | Cohort* | Democratic Republic of Congo | Wet prep | 531 HIV- FSW | TV+ women more likely to seroconvert than TV− (RR 1.7 95% CI 1.1 to 2.8) | |||
| Taha et al20 | Cohort | Malawi | Wet prep | 1169 HIV- postnatal women | TV+ women more likely to seroconvert than TV− (RR 1.88 95% CI 1.32 to 3.38) | |||
| Ghys et al21 | Cohort | Ivory Coast | Wet prep | 284 FSW | TV+ more likely to seroconvert than TV− (RR 2.4 95% CI 1.1 to 5.2) | |||
| TV+ associated with seroconversion (OR 2.77 95% CI 0.65 to 11.07) | ||||||||
| Myer et al22 | Cohort | South Africa | Wet prep | 3570 HIV- women | Baseline TV+ more likely to seroconvert compared with TV− (RR 1.84 95% CI 1.02 to 3.32) | |||
| Kleinschmidt et al23 | Cohort | South Africa | Diamond's media culture | 551 HIV-1 women | TV+ more likely to acquire HIV-1 (HR 4.8 95% CI 1.0 to 22.8) | |||
| McClelland et al9 | Cohort | Kenya | Wet prep | 1335 HIV- women, sex workers | HIV acquisition for TV+ versus TV− (RR 1.52 95% CI 1.04 to 2.24) | |||
| Van Der Pol et al24 | Nested case-control | Zimbabwe and Uganda | NAAT | 213 cases. 419 controls all women | HIV acquisition for TV+ compared with TV− (OR 2.74 95% CI 1.25 to 6.00) | |||
| Mavedzenge et al25 | Cohort | Zimbabwe and South Africa | NAAT | 4969 women in general population | HR for HIV acquisition with TV 2.05 (95% CI 1.05 to 4.02) | |||
| Delany-Moretlwe et al26 | cohort | South Africa | Not noted | 2508 HIV- women | TV+ more likely than TV− to seroconvert (RR 2.3 95% CI 1.1 to 4.9) | |||
| Vandepitte et al27 | Cohort | Uganda | InPouch culture | 1027 sex workers | HR for HIV acquisition with TV 2.72 (95% CI 1.27 to 5.84) | |||
| Couples studies | ||||||||
| Quinn et al28 | Cohort | Uganda | InPouch culture | 415 HIV serodiscordant couples | Risk of acquisition of HIV when HIV+ person has TV (RR 1.27 95% CI 0.65 to 2.35) | |||
| Hester and Kennedy29 | Nest case control | Zambia | Wet prep | 45 HIV seroconverting women and 45 controls | HIV acquisition among women TV+ baseline compared with TV− baseline (OR 2.77 95% CI 0.83 to 9.19) | |||
| Hughes et al30 | Cohort | Eastern and Southern Africa | NAAT | 3297 serodiscordant couples | HIV acquisition per-act for TV+ versus TV− (RR 2.57 95% CI 1.43 to 4.65) | |||
*Cohorts overlapped.
FSW, female sex worker; NAAT, nucleic acid amplification technique; TV, Trichomonas vaginalis.