Table 1

Trichomonas and HIV acquisition

AuthorStudy designCountryTesting methodSampleMain finding
Laga et al18Nested case-control*Democratic Republic of CongoWet prep431 HIV- womenTV+ women more likely to seroconvert (OR 1.9 95% CI 0.9 to 4.1)
Laga et al19Cohort*Democratic Republic of CongoWet prep531 HIV- FSWTV+ women more likely to seroconvert than TV− (RR 1.7 95% CI 1.1 to 2.8)
Taha et al20CohortMalawiWet prep1169 HIV- postnatal womenTV+ women more likely to seroconvert than TV− (RR 1.88 95% CI 1.32 to 3.38)
Ghys et al21CohortIvory CoastWet prep284 FSWTV+ more likely to seroconvert than TV− (RR 2.4 95% CI 1.1 to 5.2)
TV+ associated with seroconversion (OR 2.77 95% CI 0.65 to 11.07)
Myer et al22CohortSouth AfricaWet prep3570 HIV- womenBaseline TV+ more likely to seroconvert compared with TV− (RR 1.84 95% CI 1.02 to 3.32)
Kleinschmidt et al23CohortSouth AfricaDiamond's media culture551 HIV-1 womenTV+ more likely to acquire HIV-1 (HR 4.8 95% CI 1.0 to 22.8)
McClelland et al9CohortKenyaWet prep1335 HIV- women, sex workersHIV acquisition for TV+ versus TV− (RR 1.52 95% CI 1.04 to 2.24)
Van Der Pol et al24Nested case-controlZimbabwe and UgandaNAAT213 cases. 419 controls all womenHIV acquisition for TV+ compared with TV− (OR 2.74 95% CI 1.25 to 6.00)
Mavedzenge et al25CohortZimbabwe and South AfricaNAAT4969 women in general populationHR for HIV acquisition with TV 2.05 (95% CI 1.05 to 4.02)
Delany-Moretlwe et al26cohortSouth AfricaNot noted2508 HIV- womenTV+ more likely than TV− to seroconvert (RR 2.3 95% CI 1.1 to 4.9)
Vandepitte et al27CohortUgandaInPouch culture1027 sex workersHR for HIV acquisition with TV 2.72 (95% CI 1.27 to 5.84)
Couples studies
Quinn et al28CohortUgandaInPouch culture415 HIV serodiscordant couplesRisk of acquisition of HIV when HIV+ person has TV (RR 1.27 95% CI 0.65 to 2.35)
Hester and Kennedy29Nest case controlZambiaWet prep45 HIV seroconverting women and 45 controlsHIV acquisition among women TV+ baseline compared with TV− baseline (OR 2.77 95% CI 0.83 to 9.19)
Hughes et al30CohortEastern and Southern AfricaNAAT3297 serodiscordant couplesHIV acquisition per-act for TV+ versus TV− (RR 2.57 95% CI 1.43 to 4.65)
  • *Cohorts overlapped.

  • FSW, female sex worker; NAAT, nucleic acid amplification technique; TV, Trichomonas vaginalis.