Trichomonas and HIV genital shedding
| Author | Study design | Country | Testing method | Sample | Main finding | ||
|---|---|---|---|---|---|---|---|
| Clemetson, 199336 | Cross-sectional | Kenya | Wet prep | 97 HIV+ women | TV was not associated with detectable vaginal HIV (OR 0.8 95% CI 0.2 to 4.1) | ||
| Ghys, 199737 | Cross-sectional | Ivory Coast | Wet prep | 1201 female sex workers | Among HIV+ women there was no association between TV and genital HIV shedding (OR 0.9 95% CI 0.6 to 1.4) | ||
| Mostad et al8 | Cross-sectional | Kenya | Wet prep | 318 HIV+ women | TV was not associated with increased genital HIV shedding (OR 0.5 95% CI 0.1 to 1.8) | ||
| John, 199738 | Nested case-control study | Kenya | PCR | HIV+ n=21 HIV− n=42 women | There was no association between TV and genital HIV shedding (OR 0.9 95% CI 0.3 to 2.7) | ||
| Hobbs, 1999 39 | Cross-sectional | Malawi | Wet prep | All HIV+ men; TV+ n=6, TV− n=18 | Among HIV+ men, TV+ had higher rates of genital HIV shedding compared with those who were TV− 3.45 versus 0.05 per 105/ml | ||
| Kovacs, 200140 | Cross-sectional | USA | Wet prep | 311 HIV+ women | Genital HIV shedding is higher is women with TV+ (OR 4.7 95% CI 0.6 to 37.9) | ||
| Spinillo, 200141 | Cohort | Italy | Culture | 122 HIV+ women | No association between genital HIV shedding and TV (OR 0.24 95% CI 0.24 to 0.02±2.73) | ||
| Price, 200342 | Cohort | Malawi | PCR | HIV+ men: 5 TV+, 43 TV− | TV+ men had higher genital HIV than TV− (35 000 vs 1800, p<0.06) | ||
| Cu Uvin, 200643 | Cohort | USA | Wet prep | 97 HIV+ women | HIV+ women with TV+ more likely to having detectable genital HIV than TV– (OR 2.4 95% CI. 0.5 to 11.3) adjusting for plasma viral load | ||
| Neely, 200744 | Cross-sectional | USA | Wet prep | 290 HIV+ women | TV+ associated with increased genital HIV shedding (OR 1.25 95% CI 0.26 to 6.01) | ||
| Kissinger, 200945 | Cohort | USA | InPouch Culture | All HIV+ women: 58 TV+ and 92 TV− | TV+ more likely to having detectable genital HIV than TV– (OR 2.33 95% CI 1.11 to 4.90) | ||
| Paz-Bailey, 201046 | Cross-sectional | South Africa | PCR | 379 HIV+ men | HIV+ men with TV had higher ulcer viral load that men without TV (mean difference 0.62; 95% CI 0.07 to 1.2) | ||
| Tanton, 201147 | Cross-sectional | Tanzania | Wet prep | 482 HIV+ women | Prevalence of genital shedding higher in TV+ compared with TV− (OR 1.56 95% CI 1.12 to 2.17) | ||
| Couple study | |||||||
| Quinn et al28 | Cohort | Uganda | InPouch culture | 415 HIV serodiscordant couples | Risk of transmission when HIV+ person has TV (RR 1.84 95% CI 0.84 to 3.89) | ||
| Meta-analysis and review paper | |||||||
| Johnson, 200848 | Meta-analysis | Various | Various | 9 studies included | HIV+TV− both genders effect of TV on genital shedding (OR 0.9 95% CI 0.7 to 1.3) | ||
| Rottingen, 200149 | Review paper | Various | Various | 9 studies included | TV associated with increased genital transmission probability (effect measure 1.5 95% CI 1.2 to 2.0) | ||
TV, Trichomonas vaginalis.