Table 3

TV treatment and HIV shedding

AuthorStudy designCountryTesting methodSampleMain finding
Wang, 200151CohortKenyaInPouch culture or wet prep55 HIV+/TV+ women not receiving ARTHIV-1 RNA genital shedding was lower after treatment for TV from 3.67 to 3.05 Log10 copies/swab
Price, 200342CohortMalawiPCR and Culture urethral swab and urineHIV+ men: 5 TV+, 43 TV−HIV RNA in genital specimens lower for TV+ 2 weeks after treatment compared with TV− controls
Kissinger, 200945CohortUSAInPouch Culture58 HIV+/TV+ women who were successfully treated versus 92 HIV+/TV− controlsEffective treatment for TV reduced vaginal shedding (RR 0.34 95% CI 0.12 to 0.92) after adjusting for ART treatment
Masese, 201152Cross-sectionalKenyaWet prep31 HIV+/TV+ all on ART using wet prepAfter TV treatment TV+ were no less likely to have genital HIV shedding than those who were TV− (OR 0.68 95% CI 0.13 to 3.45)
Anderson, 201250CohortSouth AfricaRapid immunochromatographic test9 HIV+/TV+ womenGenital tract viral load decreased by 0.5 log10 after successful TV treatment (p<0.01)
Meta-analysis and review paper
Johnson, 200848Meta-analysisVariousVarious9 studiesEffect measure (0.9 95% CI 0.7 to 1.3)
  • ART, antiretroviral therapy; TV, Trichomonas vaginalis.