Table 3

TV treatment and HIV shedding

Author	Study design	Country	Testing method	Sample	Main finding
Wang, 2001⁵¹	Cohort	Kenya	InPouch culture or wet prep	55 HIV+/TV+ women not receiving ART	HIV-1 RNA genital shedding was lower after treatment for TV from 3.67 to 3.05 Log₁₀ copies/swab
Price, 2003⁴²	Cohort	Malawi	PCR and Culture urethral swab and urine	HIV+ men: 5 TV+, 43 TV−	HIV RNA in genital specimens lower for TV+ 2 weeks after treatment compared with TV− controls
Kissinger, 2009⁴⁵	Cohort	USA	InPouch Culture	58 HIV+/TV+ women who were successfully treated versus 92 HIV+/TV− controls	Effective treatment for TV reduced vaginal shedding (RR 0.34 95% CI 0.12 to 0.92) after adjusting for ART treatment
Masese, 2011⁵²	Cross-sectional	Kenya	Wet prep	31 HIV+/TV+ all on ART using wet prep	After TV treatment TV+ were no less likely to have genital HIV shedding than those who were TV− (OR 0.68 95% CI 0.13 to 3.45)
Anderson, 2012⁵⁰	Cohort	South Africa	Rapid immunochromatographic test	9 HIV+/TV+ women	Genital tract viral load decreased by 0.5 log₁₀ after successful TV treatment (p<0.01)
Meta-analysis and review paper
Johnson, 2008⁴⁸	Meta-analysis	Various	Various	9 studies	Effect measure (0.9 95% CI 0.7 to 1.3)