Biological pathway analysis of cytokine functions
| Biological pathway | Cell type | Cytokines assessed (n) | Number of cytokines >2-fold upregulated (n (%)) | ||||
|---|---|---|---|---|---|---|---|
| Chlamydia | Gonorrhoea | HSV-2 | Trichomoniasis | BV | |||
| Cellular trafficking | All cell types | 35 | 28 (80) | 23 (66) | 12 (34) | 4 (11) | 2 (6) |
| Leukocyte | 31 | 24 (77) | 20 (65) | 11 (35) | 4 (13) | 2 (6) | |
| T cell | 12 | 11 (92) | 8 (67) | 5 (42) | 2 (17) | 0 (0) | |
| NK cell | 7 | 6 (86) | 6 (86) | 3 (43) | 1 (14) | 0 (0) | |
| Phagocyte | 24 | 20 (83) | 17 (71) | 14 (58) | 4 (17) | 2 (8) | |
| Monocyte | 18 | 15 (83) | 13 (72) | 9 (50) | 3 (17) | 1 (6) | |
| DC | 10 | 7 (70) | 6 (60) | 5 (50) | 2 (20) | 1 (10) | |
| Neutrophil | 13 | 12 (92) | 9 (69) | 8 (62) | 1 (8) | 2 (15) | |
| Granulocyte | 19 | 15 (79) | 13 (68) | 9 (47) | 3 (16) | 2 (11) | |
| Eosinophil | 13 | 11 (85) | 9 (69) | 6 (46) | 2 (15) | 1 (8) | |
| Endothelial | 11 | 10 (91) | 7 (64) | 5 (45) | 1 (9) | 0 (0) | |
| Growth and proliferation | All cell types | 35 | 29 (83) | 25 (71) | 15 (43) | 4 (11) | 2 (6) |
| Death and viability | All cell types | 33 | 26 (79) | 21 (64) | 13 (39) | 4 (12) | 2 (6) |
| Activation | All cell types | 28 | 22 (79) | 19 (68) | 14 (50) | 5 (18) | 1 (4) |
| Differentiation | All cell types | 27 | 20 (74) | 17 (63) | 12 (44) | 3 (11) | 2 (7) |
BV, bacterial vaginosis; DC, dendritic cell; HSV-2, herpes simplex virus type 2; NK, natural killer.