Theme | Factor | Number of studies | Effect size | Homogeneity index, Q | Between-study variability, I2 |
---|---|---|---|---|---|
HPV vaccine attitudes | Perceived HPV vaccine benefits | 335 42 52 | 0.51 (0.31, 0.66), p<0.001 | 6.03, p<0.05 | 83.42 |
Anticipatory regret if not vaccinated | 29 51 | 0.27 (0.21, 0.32), p<0.001 | 0.59, p=0.44 | 0.00 | |
Perceived HPV vaccine effectiveness | 69 31 37 42 44 51 | 0.19 (0.12, 0.26), p<0.001 | 12.01, p<0.05 | 58.36 | |
Fear of needles | 430 31 36 40 | −0.11 (−0.21, −0.00), p<0.05 | 2.38, p=0.49 | 0.00 | |
Fear of side effects | 724 30 35–37 40 44 | −0.09 (−0.14, −0.04), p<0.01 | 3.95, p=0.56 | 0.00 | |
HPV vaccine endorsements | HCP recommended HPV vaccine | 59 24 30 31 51 | 0.42 (0.13, 0.64), p<0.01 | 50.84, p<0.01 | 92.13 |
Partner thinks should get vaccine | 224 44 | −0.41 (−0.51, −0.31), p<0.001 | 1.62, p=0.20 | 38.32 | |
Supportive/accepting social environment | 430 35 36 44 | 0.18 (0.08, 0.27), p<0.001 | 4.82, p=0.19 | 37.65 | |
HPV risk perceptions | Perceived HPV risk/susceptibility | 109 31 35–37 40 42 45 49 51 | 0.25 (0.15, 0.34), p<0.001 | 40.99, p<0.01 | 78.05 |
Perceived HPV severity | 79 30 35 40 42 49 51 | 0.09 (0.03, 0.16), p<0.001 | 11.05, p=0.09 | 45.73 | |
Behavioural risk indicators | Number of lifetime sexual partners | 637 42 44–46 52 | 0.18 (0.09, 0.28), p<0.01 | 11.95, p<0.05 | 58.16 |
Have a current/recent sex partner | 624 35 36 40 42 46 | 0.17 (0.04, 0.30), p<0.05 | 25.72, p<0.01 | 80.56 | |
Did not receive hepatitis B vaccine | 29 51 | −0.16 (−0.02, −0.08), p<0.001 | 1.02, p=0.31 | 2.84 | |
Smokes cigarettes | 49 24 44 51 | 0.12 (0.02, 0.22), p<0.05 | 7.06, p=0.07 | 57.50 | |
History of STI | 430 40 44 51 | 0.10 (0.01, 0.18), p<0.05 | 2.99, p=0.39 | 0.00 | |
HPV education | HPV awareness | 424 42 46 51 | 0.17 (0.05, 0.30), p<0.01 | 8.83, p<0.05 | 66.02 |
HPV knowledge | 109 30 31 34 35 42 45 46 50 51 | 0.09 (0.01, 0.16), p<0.05 | 37.84, p<0.01 | 76.22 | |
Structural barriers | Cost | 730 31 35 36 40–42 | −0.17 (−0.25, −0.07), p<0.001 | 31.94, p<0.01 | 81.22 |
Logistical barriers (hassle, time) | 69 30 36 42 44 51 | −0.16 (−0.32, −0.00), p<0.05 | 49.20, p<0.01 | 89.84 | |
Need for multiple shots | 230 31 | −0.16 (−0.27, −0.05), p<0.01 | 0.23, p=0.89 | 0.00 | |
Socio-demographic characteristics | Employed | 39 36 51 | 0.13 (0.03, 0.22), p<0.05 | 0.49, p=0.78 | 0.00 |
Non-white ethnicity | 89 30 31 35 42 44 45 51 | 0.09 (0.03, 0.15), p<0.01 | 6.86, p=0.44 | 0.00 | |
Education | 99 30 31 35–37 44 49 51 | 0.08 (−0.00, 0.16), p=0.054 | 15.95, p<0.05 | 49.86 |
HCP, healthcare providers; STI, sexually transmitted infection.