Prevalence of antibodies | Association of antibodies with diagnoses | |||||||
---|---|---|---|---|---|---|---|---|
Cases Pos. antibody/tested | Controls Pos. antibody/tested | Unadjusted | Adjusted† | |||||
n/N | Per cent | n/N | Per cent | OR | 95% CI | OR† | 95% CI | |
Infertility, women‡ | ||||||||
M. genitalium | 13/239 | 5.4 | 4/244 | 1.6 | 3.45 | 1.10 to 10.75 | 3.00 | 0.95 to 9.47 |
C. trachomatis* | 59/244 | 24.2 | 38/244 | 15.6 | 1.72 | 1.09 to 2.73 | 1.55 | 0.97 to 2.47 |
M. genitalium and C. trachomatis§ | 9/186 | 4.8 | 0/202 | 0 | 2.14 | 1.92 to 2.39 | ||
TFI¶ | ||||||||
M. genitalium | 4/44 | 9.1 | 9/195 | 4.6 | 2.07 | 0.60 to 7.05 | 1.20 | 0.32 to 4.40 |
C. trachomatis* | 20/46 | 43.5 | 39/198 | 19.7 | 3.14 | 1.58 to 6.20 | 3.16 | 1.53 to 6.51 |
M. genitalium and C. trachomatis§ | 4/29 | 13.8 | 5/157 | 3.2 | 4.86 | 1.22 to 19.36 | ||
Infertility, men | ||||||||
M. genitalium | 2/243 | 0.8 | ||||||
C. trachomatis* | 49/243 | 20.2 |
Serum was retrievable from 239 and 243 of the infertile women and men, respectively, and 244 of the control women, for M. genitalium IgG analysis.
Significant ORs highlighted in bold.
*C. trachomatis IgG antibodies are previously published5 and are included in the table for comparative reasons and the possibility to perform multivariate analysis.
†Variables included in the model were M. genitalium and C. trachomatis IgG serum antibodies. M. genitalium and C. trachomatis could not be included due to few/zero cases in some groups.
‡Women from infertile couples compared with spontaneously pregnant women without infertility.
§Women positive to both M. genitalium and C. trachomatis IgG antibodies compared with women negative to both antibodies.
¶Women with TFI diagnosed by laparoscopy and/or hysterosalpingosonography compared with all other women from infertile couples.
IgG, immunoglobulin G; TFI, tubal factor infertility.