Diagnostic accuracy characteristics for rapid tests for Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis, compared with PCR and rapid plasma reagin (RPR) and Treponema pallidum haemagglutination assay (TPHA) tests for syphilis
| POC test | N | TP | FN | FP | TN | SENSItivity (95% CI) | SPECIFICIty (95% CI) | LR (+) | LR (−) |
|---|---|---|---|---|---|---|---|---|---|
| N. gonorrhoeae | |||||||||
| Acon for NG | 773 | 0 | 8 | 21 | 744 | NQ* | 97.2 (96 to 98.5) | NQ | NQ |
| Acon Duo | 491 | 1 | 7 | 1 | 482 | 12.5 (0 to 41.7) | 99.8 (99.3 to 100) | 60.4 | 0.9 |
| C. Trachomatis | |||||||||
| Acon for CT | 229 | 5 | 17 | 0 | 207 | 22.7 (2.9 to 42.5) | 100 (99.7 to 100) | NQ | 0.8 |
| Acon Duo | 491 | 18 | 41 | 1 | 431 | 30.5 (17.9 to 43.1) | 99.8 (99.2 to 100) | 131.8 | 0.7 |
| Quick view | 664 | 20 | 33 | 4 | 607 | 37.74 (23.7 to 51.7) | 99.4 (98.6 to 100) | 57.6 | 0.6 |
| Syphilis | |||||||||
| Acon | 1439 | 12 | 0 | 17 | 1410 | 100 (95.8 to 100) | 98.8 (98.2 to 99.4) | 84.0 | NQ |
| SD Bioline | 1400 | 11 | 1 | 17 | 1371 | 91.6 (71.8 to 100) | 98.8 (98.2 to 99.4) | 74.3 | 0.1 |
*Not quantifiable.
FN, false negative; FP, false positive; LR, likelihood ratio; N, number; NQ, not quantifiable; POC, point of care; TN, true negative; TP, true positive.