Pooled sensitivity and specificity for CIN2+ and CIN3+ using the careHPV test in clinician-collected and self-collected cervical swabs
| CIN2+ | CIN3+ | |||||||||
| N study populations (N women) | Sensitivity (%, 95% CI) | I2 | Specificity (%, 95% CI) | I2 | N study populations (N women) | Sensitivity (%, 95% CI) | I2 | Specificity (%, 95% CI) | I2 | |
| All women | ||||||||||
| Clinician-collected cervical swab | 12 (n=29 657) | 88.1 (81.4 to 92.7) | 79.5% | 83.7 (74.9 to 89.8) | 99.4% | 8 (n=27 845) | 90.3 (83.4 to 94.5) | 32.9% | 85.3 (73.1 to 92.5) | 99.6% |
| Self-collected vaginal swab | 8 (n=28 120) | 73.6 (64.9 to 80.8) | 77.3% | 88.0 (79.1 to 93.5) | 99.3% | 6 (n=26 902) | 75.2 (66.8 to 82.0) | 66.0% | 90.6 (83.4 to 94.9) | 99.5% |
| General population | ||||||||||
| Clinician-collected cervical swab | 9 (n=28 442) | 84.9 (76.8 to 90.5) | 83.7% | 88.6 (76.8 to 90.5) | 99.0% | 6 (N=26 902) | 89.4 (82.2 to 93.9) | 64.5% | 90.6 (84.3 to 94.5) | 99.5% |
| Self-collected vaginal swab | 7 (N=27 848) | 72.2 (62.7 to 80.1) | 82.1% | 90.2 (83.5 to 94.4) | 99.4% | 6 (n=26 902) | 75.2 (66.8 to 82.0) | 66.0% | 90.6 (83.4 to 94.9) | 99.5% |