Table 5

POC platforms—CT, NG and CT/NG: summary of selected analytical and operational characteristics

CompanyCepheidAtlas GeneticsAlereMolbio/bigTecUstar
Assay nameGeneXpert
Atlas io
CT; CT/NG (pipeline)
Alere i
CT/NG (pipeline)
Truelab PCR
CT, NG (pipeline)
RT CPA HIV-1 Viral Load
CT (pipeline)
Use settingTabletop, not portable
Level 2—district hospital
Tabletop; portable
Level 1—health centre
Tabletop; portable
Level 1—health centre
2 instruments; not portable; Level 2—district hospitalLevel 2—district hospital
SpecimenFemale and male urine, endocervical swab/patient-collected vaginal swabSelf-collected and clinician-collected vaginal swabs from symptomatic and asymptomatic women, and urine from menFemale and male urine, endocervical swab/patient-collected vaginal swabTBDTBD
Steps~4; sample preparation automated~4; automated sample preparation on instrument~6 simple steps; raw sample added to deviceMultiple pipetting steps~3–5 steps from sample to result
Time to result~90 min30 min<60 min
Cold chain; reagent stabilityNo; TBDCartridges with reagents stable at 2°C–25°CNo; >12 monthsNo; 3 months at temperatures to 40°C
PowerMains power required; solar power possibleMains power requiredAC mains and DC from external AC/DC supplied plug packRechargeable lithium ion batteryMains power or rechargeable battery
TrainingLess than 0.5 dayLess than 1 hour; no formal training required; self-explanatory user guide and screens on instrumentLess than 0.5 dayLess than 0.5 dayApproximately 0.5 day
ConnectivityYes; computer/internet required; remote calibrationYes; via middlewareYes; USB and Ethernet outletsYes; wireless connectivityWill be used with Genie device; TBD
Equipment cost (US$); per test cost~$17 000 (with 4 modules), but could be higher; $16.20 (CT/NG)TBDTBD~$8000; TBD<$5000; TBD
  • AC, alternating current; CT, Chlamydia trachomatis; DC, direct current; NG, Neisseria gonorrhoeae; POC, point of care; TBD, to be determined.