Table 2

Resistance mechanisms in isolates with mosaic penA alleles

CouplePartnerSiteNG-MASTMLSTPEN MIC (mg/L)CRO MIC (mg/L)CIP MIC (mg/L)TET MIC (mg/L)SP MIC (mg/L)AZI MIC (mg/L)Phenotypic bla penA mtr promoter mtrR ponA gyrA parC 23S (WT:Alt)
24AUrethra1407190120.0616≤4≤640.25NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
24BRectal1407190120.0616≤4≤640.25NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
23BUrethra359812610.016≤0.03≤4≤640.125NDNovel Mosaic XLIWTG45DWTWTWT4:0
23BRectal359812610.016≤0.03≤4≤640.125NDNovel Mosaic XLIWTG45DWTWTWT4:0
23APharyngeal359812610.016≤0.03≤4≤640.125NDNovel Mosaic XLIWTG45DWTWTWT4:0
3AUrethra482219010.50.034≤4≤64≤0.06NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
3BRectal482219010.50.034≤4≤64≤0.06NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
3BPharyngeal4822190110.034≤4≤64≤0.06NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
6AUrethra4822190120.0616≤4≤640.25NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
6BPharyngeal4822190120.068≤4≤640.125NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
6BRectal4822190120.068≤4≤640.125NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
33AUrethra1407736010.038≤4≤640.25NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
33BRectal1407736010.068≤4≤640.25NDMosaic XXXIV–AWTL421PS91F, D95GS87R4:0
  • Alt, alternate allele; AZI, azithromycin; CIP, ciprofloxacin; CRO, ceftriaxone; MIC, minimum inhibitory concentration; MLST, multilocus sequence typing; ND, not detected; NG-MAST, Neisseriagonorrhoeae multiantigen sequence typing; PEN, penicillin; SP, spectinomycin; TET, tetracycline; WT, wild-type.