Table 1

Clinical manifestations of Jarisch–Herxheimer reaction (JHR) and clinical characteristics of patients with and without JHR

JHR reaction
(cases)
FeverIrritabilityRapid pulse and breathing Exacerbation of existing rashChillsLaboured breathing and hypoxaemia
11
95% CI of percentage
11 (100%)
72.0% to 100%
11 (100%)
72.0%–100%
11 (100%)
72.0% to 100%
5 (45.6%)
17.0% to 77.0%
3 (27.3%)
6.0% to 61.0%
1 (9.1%)
0% to 41.0%
Patients with JHR (11 cases)Patients without JHR (49 cases)
Patients with
Bone syphilis*9 (81.8%, 48.0% to 98.0%)15 (30.6%, 18.0% to 45.0%)
Skin damage†10 (90.9%, 59.0% to 100.0%)25 (51.0%, 36.0% to 66.0%)
Thrombocytopenia†1 (9.1%, 0% to 41.0%)7 (14.3%, 6.0% to 27.0%)
Anaemia†8 (72.7%, 39.0% to 94.0%)24 (49.0%, 34.0% to 64.0%)
Liver function damage†8 (72.7%, 39.0% to 94.0%)18 (36.7%, 24.0% to 52.0%)
Syphilitic nephropathy†4 (36.4%, 11.0% to 69.0%)8 (16.3%, 7.0% to 30.0%)
Neurosyphilis†3 (27.3%, 6.0% to 61.0%)13 (26.5%, 15.0% to 41.0%)
At least three organs affected*10 (90.9%, 59.0% to 100.0%)19 (38.8%, 25.0% to 54.0%)
Rapid plasma reagin≥1:256*‡10 (90.9%, 59.0% to 100.0%)20 (40.8%, 27.0% to 56.0%)
White blood cells† (×109/L)15.0±5.015.6±9.9
C-reactive protein† (mg/L)43.9±33.031.8±40.8
Procalcitonin† (ng/mL)0.8±0.62.7±10.0
Fluorescent treponemal antibody absorption immunoglobulin M† (positive rate)10 (90.9%, 59.0% to 100.0%)34 (69.4%, 55.0% to 82.0%)
  • 95% CI, 95% confidence limits.

  • *p<0.05,†p>0.05, comparison between the two groups.

  • ‡The value of rapid plasma reagin ranged from 1:1 to 1:256 in this study.